Ramos-Rodriguez David H, Leach J Kent
Department of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA.
Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA.
Biomater Biosyst. 2023 Jun 7;11:100080. doi: 10.1016/j.bbiosy.2023.100080. eCollection 2023 Sep.
Spheroids are three-dimensional cell aggregates that mimic fundamental aspects of the native tissue microenvironment better than single cells, making them a promising platform for the study of tissue development and therapeutics. Spheroids have been investigated for decades as models in cancer research, yet we have only just scratched the surface of their potential clinical utility in cell-based therapies. Like many cells, spheroids commonly exhibit a loss of key attributes upon implantation, motivating the need for strategies to regulate their function . Biomaterials offer numerous opportunities to preserve spheroid function and guide spheroid behavior by tailoring the local microenvironment.
球体是三维细胞聚集体，与单细胞相比，它能更好地模拟天然组织微环境的基本特征，使其成为研究组织发育和治疗方法的一个有前景的平台。几十年来，球体一直作为癌症研究的模型进行研究，但我们才刚刚触及它们在基于细胞的疗法中潜在临床应用的表面。与许多细胞一样，球体在植入后通常会失去关键属性，这就促使人们需要制定策略来调节它们的功能。生物材料通过调整局部微环境，为保留球体功能和引导球体行为提供了众多机会。
