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用于组织工程的磁性纳米颗粒功能化生物材料：优势与挑战并存

Biomaterials functionalized with magnetic nanoparticles for tissue engineering: Between advantages and challenges.

作者信息

Goranov V

机构信息

BioDevice Systems s.r.o., Bulharska 996/20, Praha 10, Czech Republic.

出版信息

Biomater Biosyst. 2024 Aug 31;15:100100. doi: 10.1016/j.bbiosy.2024.100100. eCollection 2024 Sep.

DOI:10.1016/j.bbiosy.2024.100100
PMID:39297073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11409007/
Abstract

The integration of magnetic nanoparticles (MNPs) into biomaterials offers exciting opportunities for tissue engineering as they enable better control over cell guidance, release of bioactive factors and tissue maturation. Despite their potential, challenges such as the heterogeneity of MNPs, their cytotoxicity and the need for precise control of MNP`s properties hinder their widespread application. Overcoming these challenges will require new interdisciplinary efforts and technological advances, including the development of mathematical tools and additional elaborations to ensure the biocompatibility of MNPs.

摘要

将磁性纳米颗粒（MNPs）整合到生物材料中为组织工程提供了令人兴奋的机遇，因为它们能够更好地控制细胞引导、生物活性因子的释放以及组织成熟。尽管具有潜力，但诸如MNPs的异质性、它们的细胞毒性以及对MNPs特性进行精确控制的需求等挑战阻碍了它们的广泛应用。克服这些挑战将需要新的跨学科努力和技术进步，包括开发数学工具以及进一步的阐述以确保MNPs的生物相容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/11409007/9c9dc7d0296d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/11409007/9c9dc7d0296d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/11409007/9c9dc7d0296d/gr1.jpg

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2
Magnetic nanosystem a tool for targeted delivery and diagnostic application: Current challenges and recent advancement.磁性纳米系统：靶向递送与诊断应用的工具——当前挑战与最新进展
Int J Pharm X. 2024 Jan 23;7:100231. doi: 10.1016/j.ijpx.2024.100231. eCollection 2024 Jun.
3
Artificial Intelligence-Based 3D Printing Strategies for Bone Scaffold Fabrication and Its Application in Preclinical and Clinical Investigations.
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Heliyon. 2024 Nov 7;11(1):e40104. doi: 10.1016/j.heliyon.2024.e40104. eCollection 2025 Jan 15.
基于人工智能的骨支架制造3D打印策略及其在临床前和临床研究中的应用
ACS Biomater Sci Eng. 2024 Feb 12;10(2):677-696. doi: 10.1021/acsbiomaterials.3c01368. Epub 2024 Jan 22.
4
Software for evaluation of immune cell activation (Application note).免疫细胞激活评估软件（应用说明）。
Biosystems. 2024 Jan;235:105092. doi: 10.1016/j.biosystems.2023.105092. Epub 2023 Dec 2.
5
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6
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Front Chem. 2022 Oct 11;10:1040492. doi: 10.3389/fchem.2022.1040492. eCollection 2022.
7
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Bioact Mater. 2021 Jul 23;9:105-119. doi: 10.1016/j.bioactmat.2021.07.020. eCollection 2022 Mar.