• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Targeting calcium signaling in Alzheimer's disease: challenges and promising therapeutic avenues.

作者信息

Song LinLin, Tang YongPei, Law Betty Yuen Kwan

机构信息

Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao Special Administration Region, China.

出版信息

Neural Regen Res. 2024 Mar;19(3):501-502. doi: 10.4103/1673-5374.380898.

DOI:10.4103/1673-5374.380898
PMID:37721273
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10581553/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d0d/10581553/f8c30a0f5b74/NRR-19-501-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d0d/10581553/f8c30a0f5b74/NRR-19-501-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d0d/10581553/f8c30a0f5b74/NRR-19-501-g001.jpg

相似文献

1
Targeting calcium signaling in Alzheimer's disease: challenges and promising therapeutic avenues.靶向阿尔茨海默病中的钙信号传导：挑战与有前景的治疗途径
Neural Regen Res. 2024 Mar;19(3):501-502. doi: 10.4103/1673-5374.380898.
2
Targeting the cannabinoid system to counteract the deleterious effects of stress in Alzheimer's disease.靶向大麻素系统以对抗阿尔茨海默病中应激的有害影响。
Front Aging Neurosci. 2022 Oct 4;14:949361. doi: 10.3389/fnagi.2022.949361. eCollection 2022.
3
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts.用天然灵感的 Diels-Alder 加合物靶向神经元钙通道和 GSK3β 治疗阿尔茨海默病。
Bioorg Chem. 2022 Dec;129:106152. doi: 10.1016/j.bioorg.2022.106152. Epub 2022 Sep 16.
4
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.衰老和阿尔茨海默病大脑中的Wnt信号通路失调
Front Cell Neurosci. 2019 May 22;13:227. doi: 10.3389/fncel.2019.00227. eCollection 2019.
5
Neuronal calcium signaling and Alzheimer's disease.神经元钙信号与阿尔茨海默病。
Adv Exp Med Biol. 2012;740:1193-217. doi: 10.1007/978-94-007-2888-2_54.
6
Modulation of L-type calcium channels in Alzheimer's disease: A potential therapeutic target.阿尔茨海默病中L型钙通道的调节：一个潜在的治疗靶点。
Comput Struct Biotechnol J. 2022 Nov 26;21:11-20. doi: 10.1016/j.csbj.2022.11.049. eCollection 2023.
7
Adenosine receptor signalling in Alzheimer's disease.阿尔茨海默病中的腺苷受体信号转导。
Purinergic Signal. 2022 Sep;18(3):359-381. doi: 10.1007/s11302-022-09883-1. Epub 2022 Jul 23.
8
Targeting neuroinflammation in Alzheimer's disease: from mechanisms to clinical applications.针对阿尔茨海默病中的神经炎症：从机制到临床应用
Neural Regen Res. 2023 Apr;18(4):708-715. doi: 10.4103/1673-5374.353484.
9
Nanomedicine-driven therapeutic interventions of autophagy and stem cells in the management of Alzheimer's disease.纳米医学驱动的自噬和干细胞治疗干预在阿尔茨海默病治疗中的应用。
Nanomedicine (Lond). 2023 Jan;18(2):145-168. doi: 10.2217/nnm-2022-0108. Epub 2023 Mar 20.
10
Calcium channel blockers and Alzheimer's disease.钙通道阻滞剂与老年痴呆症。
Neural Regen Res. 2012 Jan 15;7(2):137-40. doi: 10.3969/j.issn.1673-5374.2012.02.010.

引用本文的文献

1
Inter-Organellar Ca Homeostasis in Plant and Animal Systems.植物和动物系统中的细胞器间钙稳态
Cells. 2025 Aug 6;14(15):1204. doi: 10.3390/cells14151204.
2
Chaperone-Mediated Responses and Mitochondrial-Endoplasmic Reticulum Coupling: Emerging Insight into Alzheimer's Disease.伴侣介导的反应与线粒体-内质网偶联：对阿尔茨海默病的新见解
Cells. 2025 Jul 31;14(15):1179. doi: 10.3390/cells14151179.
3
Recent advancements in the understanding of the alterations in mitochondrial biogenesis in Alzheimer's disease.阿尔茨海默病中线粒体生物发生改变认识的最新进展。

本文引用的文献

1
Role of Aducanumab in the Treatment of Alzheimer's Disease: Challenges and Opportunities.阿杜卡奴单抗在阿尔茨海默病治疗中的作用：挑战与机遇。
Clin Interv Aging. 2022 May 18;17:797-810. doi: 10.2147/CIA.S325026. eCollection 2022.
2
Memory related molecular signatures: The pivots for memory consolidation and Alzheimer's related memory decline.记忆相关分子特征：记忆巩固及阿尔茨海默病相关记忆衰退的关键因素
Ageing Res Rev. 2022 Apr;76:101577. doi: 10.1016/j.arr.2022.101577. Epub 2022 Jan 29.
3
Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier.
Mol Biol Rep. 2025 Jan 29;52(1):173. doi: 10.1007/s11033-025-10297-6.
4
Exploration of the shared gene signatures and molecular mechanisms between Alzheimer's disease and intracranial aneurysm.阿尔茨海默病与颅内动脉瘤的共享基因特征和分子机制的探索。
Sci Rep. 2024 Oct 19;14(1):24628. doi: 10.1038/s41598-024-75694-6.
用于鼻-脑给药的纳米疗法：一种绕过血脑屏障的方法
Pharmaceutics. 2021 Nov 30;13(12):2049. doi: 10.3390/pharmaceutics13122049.
4
The Alzheimer's disease drug development landscape.阿尔茨海默病药物研发全景图。
Alzheimers Res Ther. 2021 Nov 11;13(1):186. doi: 10.1186/s13195-021-00927-z.
5
Critical Appraisal of Amyloid Lowering Agents in AD.AD 中淀粉样蛋白降低剂的关键性评价。
Curr Neurol Neurosci Rep. 2021 Jun 10;21(8):39. doi: 10.1007/s11910-021-01125-y.
6
NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases.在阿尔茨海默病中，NOX4通过线粒体代谢受损引发氧化应激诱导的脂质过氧化，从而促进星形胶质细胞的铁死亡。
Redox Biol. 2021 May;41:101947. doi: 10.1016/j.redox.2021.101947. Epub 2021 Mar 19.
7
Serum Calcium Predicts Cognitive Decline and Clinical Progression of Alzheimer's Disease.血清钙预测阿尔茨海默病的认知能力下降和临床进展。
Neurotox Res. 2021 Jun;39(3):609-617. doi: 10.1007/s12640-020-00312-y. Epub 2020 Nov 20.
8
Mitochondria and Calcium in Alzheimer's Disease: From Cell Signaling to Neuronal Cell Death.阿尔茨海默病中的线粒体与钙：从细胞信号传导到神经元细胞死亡
Trends Neurosci. 2021 Feb;44(2):136-151. doi: 10.1016/j.tins.2020.10.004. Epub 2020 Nov 4.
9
Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.限制 RyR2 开放时间可预防阿尔茨海默病相关的神经元过度兴奋和记忆丧失，但不能预防β-淀粉样蛋白沉积。
Cell Rep. 2020 Sep 22;32(12):108169. doi: 10.1016/j.celrep.2020.108169.
10
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs.经鼻腔脑递药：抗阿尔茨海默病药物的临床挑战和审批进展更新。
J Control Release. 2018 Jul 10;281:139-177. doi: 10.1016/j.jconrel.2018.05.011. Epub 2018 May 24.