Aaby P, Bukh J, Leerhøy J, Lisse I M, Mordhorst C H, Pedersen I R
J Infect Dis. 1986 Nov;154(5):858-63. doi: 10.1093/infdis/154.5.858.
We studied the occurrence of measles in vaccinated children from an urban area of Guinea-Bissau where measles causes high mortality. Vaccinated children who developed measles required more-intense exposure to become infected (they had a higher ratio of secondary cases [infected in the house] to index cases [infected outside the house]), had a lower mortality among secondary cases, and were less infectious (they generated fewer secondary cases than did unvaccinated children with measles). The attack rate among vaccinated children was significantly higher in households in which someone died of measles. Both severity of infection and development of measles in vaccinated children were related to intensity of exposure. Vaccine efficacy was 72%, and 33% of cases occurred among vaccinated children; however, most mothers remained confident that vaccinated children get milder measles. Moreover, there was significantly greater vaccination coverage among younger siblings of vaccinated children who had contracted measles than among other children in the community.
我们对几内亚比绍一个城市地区接种过疫苗的儿童中麻疹的发病情况进行了研究，在该地区麻疹导致的死亡率很高。患麻疹的接种过疫苗的儿童需要更强烈的接触才会被感染（他们家庭内二代病例[在家庭中被感染]与指示病例[在家庭外被感染]的比例更高），二代病例的死亡率较低，且传染性较小（与未接种疫苗的麻疹患儿相比，他们产生的二代病例更少）。在有麻疹死亡病例的家庭中，接种过疫苗的儿童的发病率显著更高。接种过疫苗的儿童的感染严重程度和麻疹发病情况均与接触强度有关。疫苗效力为72%，33%的病例发生在接种过疫苗的儿童中；然而，大多数母亲仍然坚信接种过疫苗的儿童患的麻疹症状较轻。此外，患麻疹的接种过疫苗的儿童的弟弟妹妹的疫苗接种覆盖率显著高于社区中的其他儿童。
