• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

钙二钠乙二胺四乙酸纳米粒子是否能降低镉对雌性大鼠的毒性作用？

Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats?

机构信息

Department of Toxicology, Forensic Medicine and Veterinary Regulations, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Immune Section, Research Institute for Animal Reproduction, Giza, Egypt.

出版信息

Biol Trace Elem Res. 2024 May;202(5):2228-2240. doi: 10.1007/s12011-023-03842-6. Epub 2023 Sep 18.

DOI:10.1007/s12011-023-03842-6
PMID:37721680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10955038/
Abstract

The present study aims to investigate the ability of CaNa2EDTA (ethylenediaminetetraacetic acid) macroparticles and nanoparticles to treat cadmium-induced toxicity in female rats and to compare their efficacies. Forty rats were divided into 4 equal groups: control, cadmium, cadmium + CaNaEDTA macroparticles and Cd + CaNaEDTA nanoparticles. Cadmium was added to the drinking water in a concentration of 30 ppm for 10 weeks. CaNaEDTA macroparticles and nanoparticles (50 mg/kg) were intraperitoneally injected during the last 4 weeks of the exposure period. Every two weeks, blood and urine samples were collected for determination of urea, creatinine, metallothionein and cadmium concentrations. At the end of the experiment, the skeleton of rats was examined by X-ray and tissue samples from the kidney and femur bone were collected and subjected to histopathological examination. Exposure to cadmium increased the concentrations of urea and creatinine in the serum and the concentrations of metallothionein and cadmium in serum and urine of rats. A decrease in bone mineralization by X-ray examination in addition to various histopathological alterations in the kidney and femur bone of Cd-intoxicated rats were also observed. Treatment with both CaNaEDTA macroparticles and nanoparticles ameliorated the toxic effects induced by cadmium on the kidney and bone. However, CaNaEDTA nanoparticles showed a superior efficacy compared to the macroparticles and therefore can be used as an effective chelating antidote for treatment of cadmium toxicity.

摘要

本研究旨在探讨 CaNa2EDTA（乙二胺四乙酸）大、纳米颗粒治疗雌性大鼠镉诱导毒性的能力，并比较其疗效。40 只大鼠被分为 4 组：对照组、镉组、镉+CaNaEDTA 大颗粒组和 Cd+CaNaEDTA 纳米颗粒组。在 10 周的时间里，给大鼠饮用含 30ppm 镉的水。在暴露期的最后 4 周内，通过腹腔注射 CaNaEDTA 大、纳米颗粒（50mg/kg）。每两周采集一次血和尿样，用于测定尿素、肌酐、金属硫蛋白和镉的浓度。实验结束时，通过 X 射线检查大鼠的骨骼，收集肾脏和股骨组织样本，进行组织病理学检查。暴露于镉会增加血清中尿素和肌酐的浓度，以及大鼠血清和尿液中金属硫蛋白和镉的浓度。X 射线检查发现骨矿化减少，镉中毒大鼠的肾脏和股骨也出现各种组织病理学改变。用 CaNaEDTA 大、纳米颗粒治疗均可改善镉对肾脏和骨骼的毒性作用。然而，与大颗粒相比，纳米颗粒的疗效更好，因此可作为治疗镉毒性的有效螯合剂解毒剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/6dc345268266/12011_2023_3842_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/d5b12dc5d319/12011_2023_3842_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/1d835c5dc56e/12011_2023_3842_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/067baf8da147/12011_2023_3842_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/a88a25a22587/12011_2023_3842_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/f665a217366c/12011_2023_3842_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/d35c0b0d87fd/12011_2023_3842_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/cc36f4b58045/12011_2023_3842_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/aeec1f345b00/12011_2023_3842_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/aa75d6ac58a9/12011_2023_3842_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/6dc345268266/12011_2023_3842_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/d5b12dc5d319/12011_2023_3842_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/1d835c5dc56e/12011_2023_3842_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/067baf8da147/12011_2023_3842_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/a88a25a22587/12011_2023_3842_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/f665a217366c/12011_2023_3842_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/d35c0b0d87fd/12011_2023_3842_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/cc36f4b58045/12011_2023_3842_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/aeec1f345b00/12011_2023_3842_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/aa75d6ac58a9/12011_2023_3842_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b5/10955038/6dc345268266/12011_2023_3842_Fig10_HTML.jpg

相似文献

1
Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats?钙二钠乙二胺四乙酸纳米粒子是否能降低镉对雌性大鼠的毒性作用？
Biol Trace Elem Res. 2024 May;202(5):2228-2240. doi: 10.1007/s12011-023-03842-6. Epub 2023 Sep 18.
2
Nephrotoxicities of aluminium and/or cadmium-metallothionein in rats: creatinine excretion and metabolism of selected essential metals.铝和/或镉金属硫蛋白对大鼠的肾毒性：肌酐排泄及特定必需金属的代谢
Pharmacol Toxicol. 1995 Aug;77(2):155-60. doi: 10.1111/j.1600-0773.1995.tb01005.x.
3
Effects of chelating agents on oral uptake and renal deposition and excretion of cadmium.螯合剂对镉的口服吸收、肾脏沉积及排泄的影响。
Environ Health Perspect. 1984 Mar;54:219-32. doi: 10.1289/ehp.54-1568190.
4
Bradykinin potentiating factor isolated from Buthus occitanus venom has a protective effect against cadmium-induced rat liver and kidney damage.从奥氏毒蛛毒液中分离得到的缓激肽增强因子对镉诱导的大鼠肝、肾损伤具有保护作用。
Tissue Cell. 2011 Dec;43(6):337-43. doi: 10.1016/j.tice.2011.07.001. Epub 2011 Aug 20.
5
Effects of exogenous metallothionein on acute cadmium toxicity in rats.外源性金属硫蛋白对大鼠急性镉中毒的影响。
Biol Trace Elem Res. 2005 Jun;104(3):223-32. doi: 10.1385/BTER:104:3:223.
6
Experimental studies on the bone metabolism of male rats chronically exposed to cadmium intoxication using dual-energy X-ray absorptiometry.使用双能X线吸收法对长期镉中毒雄性大鼠的骨代谢进行的实验研究。
Toxicol Ind Health. 2008 Apr;24(3):161-70. doi: 10.1177/0748233707078229.
7
Isolated rat hepatocytes as a model system for screening chelators for use in cadmium intoxication.
Toxicol Appl Pharmacol. 1983 Feb;67(2):257-63. doi: 10.1016/0041-008x(83)90232-6.
8
Chelation of cadmium from metallothionein in vivo and its excretion in rats repeatedly injected with cadmium chloride.
J Pharmacol Exp Ther. 1982 Sep;222(3):699-704.
9
Influence of cadmium-metallothionein pretreatment on tolerance of rat kidney cortical cells to cadmium toxicity in vitro and in vivo.镉-金属硫蛋白预处理对大鼠肾皮质细胞体外和体内镉毒性耐受性的影响。
Pharmacol Toxicol. 1987 May;60(5):345-9. doi: 10.1111/j.1600-0773.1987.tb01524.x.
10
Effect of low-level lifetime exposure to cadmium on calciotropic hormones in aged female rats.低水平终生接触镉对老年雌性大鼠钙调节激素的影响。
Arch Toxicol. 2005 Nov;79(11):636-46. doi: 10.1007/s00204-005-0680-6. Epub 2005 Jun 7.

引用本文的文献

1
Cd Stress Response in Emmer Wheat ( Schrank) Varieties Under In Vitro Conditions and Remedial Effect of CaO Nanoparticles.体外条件下二粒小麦品种的镉胁迫响应及氧化钙纳米颗粒的修复作用
Biology (Basel). 2025 Apr 9;14(4):394. doi: 10.3390/biology14040394.

本文引用的文献

1
Zinc nanoparticles ameliorate oxidative stress and apoptosis induced by silver nanoparticles in the brain of male rats.锌纳米颗粒可改善雄性大鼠大脑中由银纳米颗粒诱导的氧化应激和细胞凋亡。
Neurotoxicology. 2023 Mar;95:193-204. doi: 10.1016/j.neuro.2023.02.005. Epub 2023 Feb 14.
2
Ameliorative role of nanocurcumin against the toxicological effects of novel forms of Cuo as nanopesticides: a comparative study.纳米姜黄素对新型氧化铜纳米农药毒理学效应的改善作用：一项比较研究。
Environ Sci Pollut Res Int. 2023 Feb;30(10):26270-26291. doi: 10.1007/s11356-022-23886-w. Epub 2022 Nov 10.
3
Hepatorenal protective effect of nano-curcumin against nano‑copper oxide-mediated toxicity in rats: Behavioral performance, antioxidant, anti-inflammatory, apoptosis, and histopathology.
纳米姜黄素对纳米氧化铜诱导大鼠肝肾毒性的保护作用：行为表现、抗氧化、抗炎、细胞凋亡和组织病理学。
Life Sci. 2022 Mar 1;292:120296. doi: 10.1016/j.lfs.2021.120296. Epub 2022 Jan 16.
4
Evaluation of the Ameliorative Effect of Zinc Nanoparticles against Silver Nanoparticle-Induced Toxicity in Liver and Kidney of Rats.评价锌纳米粒子对大鼠肝肾中银纳米粒子诱导毒性的改善作用。
Biol Trace Elem Res. 2022 Mar;200(3):1201-1211. doi: 10.1007/s12011-021-02713-2. Epub 2021 Apr 14.
5
Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats.锌纳米粒子可改善银纳米粒子对雄性大鼠生殖毒性的影响。
Int J Nanomedicine. 2021 Mar 31;16:2555-2568. doi: 10.2147/IJN.S307189. eCollection 2021.
6
Influence of calcium and EDTA on copper ion bioavailability in copper nanoparticle toxicity tests improves understanding of nano-specific effects.钙和 EDTA 对铜纳米颗粒毒性试验中铜离子生物利用度的影响，提高了对纳米特异性效应的理解。
Toxicol Ind Health. 2020 Jul;36(7):467-476. doi: 10.1177/0748233720936825.
7
An assessment of sensitivity biomarkers for urinary cadmium burden.尿液镉负荷的敏感生物标志物评估。
BMC Nephrol. 2020 Sep 5;21(1):385. doi: 10.1186/s12882-020-02036-9.
8
The Effects of Cadmium Toxicity.镉毒性的影响。
Int J Environ Res Public Health. 2020 May 26;17(11):3782. doi: 10.3390/ijerph17113782.
9
Cadmium Pathways in Snails Follow a Complementary Strategy between Metallothionein Detoxification and Auxiliary Inactivation by Phytochelatins.蜗牛体内的镉代谢途径遵循金属硫蛋白解毒和植物螯合肽辅助失活之间的互补策略。
Int J Mol Sci. 2019 Dec 18;21(1):7. doi: 10.3390/ijms21010007.
10
Overcoming Hurdles in Nanoparticle Clinical Translation: The Influence of Experimental Design and Surface Modification.克服纳米颗粒临床转化中的障碍：实验设计和表面修饰的影响。
Int J Mol Sci. 2019 Nov 30;20(23):6056. doi: 10.3390/ijms20236056.