Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA; email:
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Annu Rev Pathol. 2024 Jan 24;19:11-42. doi: 10.1146/annurev-pathol-042420-092719. Epub 2023 Sep 18.
Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease.
弥漫性胸膜间皮瘤（DPM）是一种起源于覆盖胸膜表面的间皮细胞的高度侵袭性恶性肿瘤。虽然 DPM 是一种与石棉暴露有关的公认疾病，但最近的进展扩展了我们对分子发病机制的理解，并改变了我们的临床实践。本综述探讨了 DPM 的当前概念和新兴趋势，包括危险因素、病理生物学、组织学亚型和治疗管理，重点是对这种复杂疾病采用多学科方法。
