R Priya Dharshini, Grace Priyadarshini Sarah, P Jayaganesh
Department of Pathology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Sep 5;16(9):e68718. doi: 10.7759/cureus.68718. eCollection 2024 Sep.
Malignant pleural mesothelioma, an aggressive neoplasm frequently linked to asbestos exposure, is often detected at an advanced stage. This report details the case of a 58-year-old mason who presented with left-sided chest pain, and shortness of breath, accompanied by weight loss for a month. A positron emission tomography (PET) scan revealed increased uptake along the pleural surface, as well as in several mediastinal lymph nodes and the left supraclavicular lymph node. Thoracoscopy revealed the presence of multiple nodules on the costal pleura. Despite repeated negative results from pleural effusion cytology, cell block analysis, and pleural biopsies, the diagnosis of malignant mesothelioma (MM) was ultimately established through an ultrasound-guided (USG) biopsy of the left supraclavicular lymph node, with immunohistochemical confirmation using calretinin.
恶性胸膜间皮瘤是一种侵袭性肿瘤，常与接触石棉有关，通常在晚期才被发现。本报告详细介绍了一名58岁泥瓦匠的病例，该患者出现左侧胸痛、呼吸急促，并伴有一个月的体重减轻。正电子发射断层扫描（PET）显示胸膜表面、多个纵隔淋巴结和左锁骨上淋巴结摄取增加。胸腔镜检查发现肋胸膜上有多个结节。尽管胸水细胞学、细胞块分析和胸膜活检多次结果为阴性，但最终通过左锁骨上淋巴结的超声引导（USG）活检确诊为恶性间皮瘤（MM），并使用钙视网膜蛋白进行免疫组化确认。
