Luo Bozhi
School of Basic Medicine, Hengyang Medical College, University of South China, Hengyang, China.
Int J Neurosci. 2024 Nov;134(11):1256-1281. doi: 10.1080/00207454.2023.2260088. Epub 2023 Sep 21.
Studies have shown that neurodegenerative diseases such as AD and PD are related to neuroinflammation. Neuroinflammation is a common inflammatory condition that can lead to a variety of dysfunction in the body. At present, it is no medications specifically approved to prevent or cure neuroinflammation, so even though many drugs can temporarily control the neurological symptoms of neuroinflammation, but no one can reverse the progress of neuroinflammation, let al.one completely cure neuroinflammation. Therefore, it is urgent to develop new drug development for neuroinflammation treatment. In this review, we highlight the therapeutic advancement in the field of neurodegenerative disorders, by focusing on the impact of neuroinflammation treatment has on these conditions, and the effective drugs for the treatment of neuroinflammation and neurodegenerative diseases and their latest research progress are reviewed according to the related signaling pathway, as well as the prospect of their clinical application is also discussed. The purpose of this review is to enable specialists to better understand the mechanisms underlying neuroinflammation and anti-inflammatory drugs, promote the development of therapeutic drugs for neuroinflammation and neurodegenerative diseases, and further provide therapeutic references for clinical neurologists.
研究表明，阿尔茨海默病（AD）和帕金森病（PD）等神经退行性疾病与神经炎症有关。神经炎症是一种常见的炎症状态，可导致身体出现多种功能障碍。目前，尚无专门批准用于预防或治疗神经炎症的药物，因此，尽管许多药物可暂时控制神经炎症的神经症状，但无人能逆转神经炎症的进展，更不用说完全治愈神经炎症了。因此，开发用于治疗神经炎症的新药迫在眉睫。在本综述中，我们重点介绍神经退行性疾病领域的治疗进展，关注神经炎症治疗对这些疾病的影响，根据相关信号通路综述治疗神经炎症和神经退行性疾病的有效药物及其最新研究进展，并讨论其临床应用前景。本综述的目的是使专家们更好地理解神经炎症和抗炎药物的潜在机制，促进神经炎症和神经退行性疾病治疗药物的开发，并进一步为临床神经科医生提供治疗参考。
