Noguchi T, Sugisaki T
J Neurochem. 1986 Dec;47(6):1785-92. doi: 10.1111/j.1471-4159.1986.tb13089.x.
The concentration of gangliosides in the Snell dwarf mouse cerebrum was monitored from postnatal day 5 to day 40. In the dwarf cerebrum, the concentration of total gangliosides increased up to postnatal day 20 and then stopped, whereas in the control cerebrum, it continued to increase up to postnatal day 40. At postnatal day 40, the ganglioside level in the dwarf cerebrum was 70% of that in the control cerebrum. Among the ganglioside species, the concentrations of GM4, GM2, GM1, GD1a, GD3, GD1b, GT1b, and GQ1b were significantly lower in the dwarf cerebrum than in the controls at postnatal day 40. The reduced concentrations of ganglioside species GM2, GD1a, GD3, GD1b, and GQ1b were completely restored by administration of bovine growth hormone (GH) during the first 20 days of postnatal life. The reduced concentration of the GM1 and GM4 species were most efficiently restored by administration of bovine GH plus thyroxine (T4) during the second 20 days of postnatal life. These results indicate that the lower ganglioside concentrations in the dwarf cerebrum can be elevated by hormone therapy and that there exist distinct GH and T4 actions on the enzymes participating in ganglioside metabolism.
从出生后第5天到第40天监测Snell侏儒小鼠大脑中神经节苷脂的浓度。在侏儒小鼠大脑中，总神经节苷脂浓度在出生后第20天前持续升高，之后停止升高；而在对照小鼠大脑中，总神经节苷脂浓度一直持续升高到出生后第40天。在出生后第40天，侏儒小鼠大脑中的神经节苷脂水平是对照小鼠大脑中神经节苷脂水平的70%。在出生后第40天，侏儒小鼠大脑中GM4、GM2、GM1、GD1a、GD3、GD1b、GT1b和GQ1b等神经节苷脂种类的浓度显著低于对照小鼠大脑。在出生后的前20天给予牛生长激素（GH），可使神经节苷脂种类GM2、GD1a、GD3、GD1b和GQ1b降低的浓度完全恢复。在出生后的第二个20天给予牛GH加甲状腺素（T4），可最有效地恢复GM1和GM4种类降低的浓度。这些结果表明，侏儒小鼠大脑中较低的神经节苷脂浓度可通过激素治疗升高，并且GH和T4对参与神经节苷脂代谢的酶存在不同的作用。
