Noguchi T, Sugisaki T, Tsukada Y
Neurochem Pathol. 1984 Summer;2(2):123-38. doi: 10.1007/BF02834251.
An investigation of the Snell dwarf motor cortex, area 6 of Caviness, was carried out by means of a modified Golgi silver impregnation method. The pyramidal neurons located in layer V were found to have small perikarya, short primary dendrites with sparse branchings. Following administration of bovine growth hormone (bGH) and thyroxine (T4) during the first 20 d of postnatal life, this retarded neuronal growth was restored to normal: neuronal perikarya were enlarged, and the dentrites were thicker with denser branchings. These results were confirmed in the sections stained for neuron specific enolase (NSE). These findings demonstrate that exogenous GH and T4, will enhance neuronal growth in the Snell dwarf cerebrum, and restore neuronal arborization to normal.
采用改良的高尔基银浸染法对斯内尔侏儒小鼠的运动皮层（卡维尼斯第6区）进行了研究。发现位于第V层的锥体细胞胞体较小，初级树突短且分支稀疏。在出生后第1天至20天期间给予牛生长激素（bGH）和甲状腺素（T4）后，这种神经元生长迟缓恢复正常：神经元胞体增大，树突变粗且分支增多。这些结果在神经元特异性烯醇化酶（NSE）染色切片中得到证实。这些发现表明，外源性GH和T4可促进斯内尔侏儒小鼠大脑中的神经元生长，并使神经元分支恢复正常。
