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病例报告:中国一例误诊为 2019 冠状病毒病/流感的布氏杆菌病。

Case report: A case of brucellosis misdiagnosed as coronavirus disease 2019/influenza in China.

机构信息

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Akesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, China.

出版信息

Front Public Health. 2023 Sep 1;11:1186800. doi: 10.3389/fpubh.2023.1186800. eCollection 2023.

DOI:10.3389/fpubh.2023.1186800
PMID:37724314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10505428/
Abstract

Brucellosis is an important zoonosis and a multisystem disease. The signs and symptoms of brucellosis are not specific. In the clinical, brucellosis is often ignored and misdiagnosed. We report a case of brucellosis who was misdiagnosed as coronavirus disease 2019 (COVID-19)/influenza and received delayed treatment during strict COVID-19 control. The neglect of other diseases due to COVID-19 and empirical diagnosis and treatment by medical staff are part of the reasons for misdiagnosis. Otherwise, the normal erythrocyte sedimentation rate (ESR), increased white blood cell count (WBC), and increased neutrophil count (NEUT) of this patient was also a cause of misdiagnosis, which is an important reminder for diagnosis. For patients with the unknown origin of fever and other symptoms related to brucellosis, especially those from endemic areas of brucellosis, brucellosis screening is a priority item, and grassroots doctors should be vigilant and standardize the diagnosis and treatment based on epidemiology history, clinical manifestation, and laboratory tests according to the diagnostic criteria of brucellosis.

摘要

布鲁氏菌病是一种重要的人畜共患病和全身性疾病。布鲁氏菌病的体征和症状不具有特异性。在临床上,布鲁氏菌病常被忽视和误诊。我们报告了 1 例布鲁氏菌病患者,该患者在严格的 COVID-19 防控期间被误诊为 2019 年冠状病毒病(COVID-19)/流感,并接受了延迟治疗。由于 COVID-19 而忽视其他疾病,以及医务人员的经验性诊断和治疗,是误诊的部分原因。此外,该患者的正常红细胞沉降率(ESR)、白细胞计数(WBC)增加和中性粒细胞计数(NEUT)增加也是误诊的原因之一,这对诊断具有重要的提示作用。对于发热等原因不明的症状和其他与布鲁氏菌病相关的症状的患者,尤其是来自布鲁氏菌病流行地区的患者,布鲁氏菌病筛查是优先事项,基层医生应根据布鲁氏菌病的诊断标准,根据流行病学史、临床表现和实验室检查结果保持警惕并规范诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f416/10505428/3dc69b3acbcc/fpubh-11-1186800-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f416/10505428/3dc69b3acbcc/fpubh-11-1186800-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f416/10505428/3dc69b3acbcc/fpubh-11-1186800-g001.jpg

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Front Public Health. 2022 Nov 18;10:990218. doi: 10.3389/fpubh.2022.990218. eCollection 2022.
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Human brucellosis and fever of unknown origin.人布鲁氏菌病与不明原因发热。
BMC Infect Dis. 2022 Nov 21;22(1):868. doi: 10.1186/s12879-022-07872-8.
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Natural History of and Dynamic Changes in Clinical Manifestation, Serology, and Treatment of Brucellosis, China.
中国甘肃布鲁氏菌病患者抗体变化的随访
Microbiol Spectr. 2025 Jun 3;13(6):e0286224. doi: 10.1128/spectrum.02862-24. Epub 2025 Apr 30.
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Front Cell Infect Microbiol. 2025 Feb 4;15:1531018. doi: 10.3389/fcimb.2025.1531018. eCollection 2025.
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