• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Trimethylamine-N-oxide is an important target for heart and brain diseases.氧化三甲胺是心脏和脑部疾病的一个重要靶点。
Med Rev (2021). 2022 Sep 22;2(4):321-323. doi: 10.1515/mr-2022-0026. eCollection 2022 Aug.
2
Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases.三甲胺/氧化三甲胺：饮食与心血管疾病之间的关键因素
Cardiovasc Toxicol. 2021 Aug;21(8):593-604. doi: 10.1007/s12012-021-09656-z. Epub 2021 May 18.
3
Simultaneous determination of trimethylamine and trimethylamine N-oxide in mouse plasma samples by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry.亲水作用液相色谱-串联质谱法同时测定小鼠血浆样品中的三甲胺和氧化三甲胺
J Sep Sci. 2017 Feb;40(3):688-696. doi: 10.1002/jssc.201600926. Epub 2016 Dec 21.
4
Proton translocation coupled to trimethylamine N-oxide reduction in anaerobically grown Escherichia coli.在厌氧生长的大肠杆菌中，质子转运与三甲胺 N-氧化物还原相偶联。
J Bacteriol. 1981 Dec;148(3):762-8. doi: 10.1128/jb.148.3.762-768.1981.
5
Trimethylamine-N-Oxide Treatment Induces Changes in the ATP-Binding Cassette Transporter A1 and Scavenger Receptor A1 in Murine Macrophage J774A.1 cells.三甲胺 - N - 氧化物处理诱导小鼠巨噬细胞J774A.1细胞中ATP结合盒转运蛋白A1和清道夫受体A1发生变化。
Inflammation. 2016 Feb;39(1):393-404. doi: 10.1007/s10753-015-0261-7.
6
The inducible trimethylamine-N-oxide reductase of Escherichia coli K12: biochemical and immunological studies.
Biochim Biophys Acta. 1988 Apr 28;954(1):1-13. doi: 10.1016/0167-4838(88)90049-0.
7
Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice.基于人源化肝脏小鼠中氘标记三甲胺代谢谱，采用药代动力学模型外推得到的人血浆氧化三甲胺浓度。
J Toxicol Sci. 2018;43(6):387-393. doi: 10.2131/jts.43.387.
8
Human plasma and urinary metabolic profiles of trimethylamine and trimethylamine N-oxide extrapolated using a simple physiologically based pharmacokinetic model.利用简单的基于生理的药代动力学模型推断出的三甲胺和氧化三甲胺的人体血浆及尿液代谢谱。
J Toxicol Sci. 2017;42(4):485-490. doi: 10.2131/jts.42.485.
9
Formation of aliphatic amine precursors of N-nitrosodimethylamine after oral administration of choline and choline analogues in the rat.大鼠口服胆碱及胆碱类似物后N-亚硝基二甲胺脂肪胺前体的形成
Food Chem Toxicol. 1989 Jan;27(1):31-4. doi: 10.1016/0278-6915(89)90089-6.
10
Cardiovascular disease risk prediction in scleroderma.硬皮病的心血管疾病风险预测。
Rev Assoc Med Bras (1992). 2023 Mar 3;69(2):246-251. doi: 10.1590/1806-9282.20220936. eCollection 2023.

引用本文的文献

1
Gut microbiota-derived metabolite trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase.肠道微生物群衍生的代谢产物氧化三甲胺通过抑制S-腺苷同型半胱氨酸水解酶改变宿主表观基因组。
J Biol Chem. 2025 Jul 25;301(9):110521. doi: 10.1016/j.jbc.2025.110521.
2
In vivo H-MR spectroscopy and imaging of hepatic metabolic formation of trimethylamine-N-oxide.体内三甲胺-N-氧化物肝脏代谢生成的氢磁共振波谱与成像
Magn Reson Med. 2025 Aug;94(2):521-529. doi: 10.1002/mrm.30531. Epub 2025 Apr 14.
3
Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program.肠道微生物纵向信号与体重减轻相关：来自数字疗法项目的见解。
Front Nutr. 2024 Jul 8;11:1363079. doi: 10.3389/fnut.2024.1363079. eCollection 2024.

本文引用的文献

1
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism.微生物 gbu 基因簇将与食用红色肉类相关的心血管疾病风险与微生物组 L-肉碱代谢联系起来。
Nat Microbiol. 2022 Jan;7(1):73-86. doi: 10.1038/s41564-021-01010-x. Epub 2021 Dec 23.
2
Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide.微生物组相关甲基胺对血脑屏障完整性的调节作用和氧化三甲胺对认知的影响。
Microbiome. 2021 Nov 27;9(1):235. doi: 10.1186/s40168-021-01181-z.
3
Trimethylamine N-Oxide and Stroke Recurrence Depends on Ischemic Stroke Subtypes.氧化三甲胺与卒中复发取决于缺血性卒中亚型。
Stroke. 2022 Apr;53(4):1207-1215. doi: 10.1161/STROKEAHA.120.031443. Epub 2021 Nov 19.
4
Metabolic Signatures in Coronary Artery Disease: Results from the BioHEART-CT Study.冠心病的代谢特征：来自 BioHEART-CT 研究的结果。
Cells. 2021 Apr 22;10(5):980. doi: 10.3390/cells10050980.
5
Metabolites and diabetes remission after weight loss.代谢物与减肥后糖尿病缓解。
Nutr Diabetes. 2021 Feb 24;11(1):10. doi: 10.1038/s41387-021-00151-6.
6
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.抑制微生物群依赖的 TMAO 生成可减轻小鼠慢性肾脏病。
Sci Rep. 2021 Jan 12;11(1):518. doi: 10.1038/s41598-020-80063-0.
7
Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study.氧化三甲胺与心血管疾病中的胆固醇逆转运：一项横断面研究。
Sci Rep. 2020 Oct 29;10(1):18675. doi: 10.1038/s41598-020-75633-1.
8
Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.非致死性抑制肠道微生物三甲胺 N-氧化物生成可改善心力衰竭小鼠的心脏功能和重构。
J Am Heart Assoc. 2020 May 18;9(10):e016223. doi: 10.1161/JAHA.119.016223. Epub 2020 May 10.
9
Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.靶向抑制肠道微生物三甲胺 N-氧化物生成可减少慢性肾脏病小鼠模型的肾间质纤维化和功能障碍。
Arterioscler Thromb Vasc Biol. 2020 May;40(5):1239-1255. doi: 10.1161/ATVBAHA.120.314139. Epub 2020 Mar 26.
10
Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review.肠道微生物群在心血管健康和疾病中的作用：美国心脏病学会最新综述。
J Am Coll Cardiol. 2019 Apr 30;73(16):2089-2105. doi: 10.1016/j.jacc.2019.03.024.

Trimethylamine-N-oxide is an important target for heart and brain diseases.

作者信息

Ding Shusi, Xue Jing, Zhang Qi, Zheng Lemin

机构信息

China National Clinical Research Center of Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

School of Basic Medical Sciences, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, Peking University, Beijing, China.

出版信息

Med Rev (2021). 2022 Sep 22;2(4):321-323. doi: 10.1515/mr-2022-0026. eCollection 2022 Aug.

DOI:10.1515/mr-2022-0026
PMID:37724327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10388736/
Abstract
摘要