Ment L R, Stewart W B, Duncan C C, Pitt B R
J Neurosurg. 1986 Dec;65(6):847-50. doi: 10.3171/jns.1986.65.6.0847.
Asphyxia, with its attendant hypoxemia, is by far the most common cause of neonatal cerebral infarction, and frequently results in lesions of the parieto-occipital white matter in addition to other neuropathological changes. This study examines the effects of hypoxemia on regional cerebral blood flow (CBF) in the newborn beagle pup. The animals were anesthetized, underwent a tracheotomy, and were paralyzed. Pups were randomly divided into two groups: one group was subjected to hypoxemia produced by altering the oxygen concentration in the inspired air, and the other received no insult. In the hypoxemic pups, the pO2 was 13.1 +/- 2.1 mm Hg (mean +/- standard deviation). Autoradiographic determinations of CBF were performed by the carbon-14-iodoantipyrine technique 15 minutes after randomization. Significant increases in CBF were found throughout the brains of the hypoxemic pups. The CBF was increased to cortical and central gray regions and to frontal and temporal white matter but was unchanged in the parietal white matter, one of the classic sites of radiological and neuropathological injury in neonates with perinatal asphyxia. An unexpected finding was the increased incidence of germinal matrix and/or intraventricular hemorrhages in the hypoxemic pups.
窒息及其伴随的低氧血症是新生儿脑梗死最常见的病因，除其他神经病理学改变外，还常导致顶枕白质损伤。本研究探讨低氧血症对新生比格犬局部脑血流量（CBF）的影响。动物麻醉后行气管切开术并使其麻痹。幼犬被随机分为两组：一组通过改变吸入空气中的氧浓度产生低氧血症，另一组未受损伤。低氧血症幼犬的动脉血氧分压为13.1±2.1 mmHg（平均值±标准差）。随机分组15分钟后，采用碳-14-碘安替比林技术进行CBF的放射自显影测定。发现低氧血症幼犬全脑的CBF显著增加。CBF增加至皮质和中央灰质区域以及额叶和颞叶白质，但顶叶白质（围产期窒息新生儿放射学和神经病理学损伤的经典部位之一）的CBF未改变。一个意外发现是低氧血症幼犬生发基质和/或脑室内出血的发生率增加。
