Ment L R, Stewart W B, Duncan C C
J Neurosurg. 1982 Sep;57(3):384-9. doi: 10.3171/jns.1982.57.3.0384.
Local cerebral glucose utilization has been measured by means of carbon-14(14C)-autoradiography with 2-deoxyglucose in the newborn beagle puppy model of intraventricular hemorrhage. Our studies demonstrate gray matter/white matter differentiation of uptake of 14C-2-deoxyglucose in the control pups, as would be expected from adult animal studies. However, there is a marked homogeneity of 14C-2-deoxyglucose uptake in all brain regions in the puppies with intraventricular hemorrhage, possibly indicating a loss of the known coupling between cerebral blood flow and metabolism in this neuropathological condition.
在新生比格幼犬脑室内出血模型中，已通过碳-14（14C）放射自显影术和2-脱氧葡萄糖来测量局部脑葡萄糖利用率。我们的研究表明，在对照幼犬中，14C-2-脱氧葡萄糖摄取存在灰质/白质差异，这与成年动物研究的预期结果一致。然而，脑室内出血幼犬的所有脑区中，14C-2-脱氧葡萄糖摄取存在明显的均匀性，这可能表明在这种神经病理状态下，脑血流与代谢之间已知的耦合关系丧失。
