Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
J Interferon Cytokine Res. 2023 Sep;43(9):359-362. doi: 10.1089/jir.2023.0122.
It has now been 20 years since the original discovery of the interferon λ (IFN-λ) family (Kotenko et al., 2003; Sheppard et al., 2003) and 10 years since the subsequent discovery of IFN-λ4 (Prokunina-Olsson et al., 2013). The IFN-λ family (type III IFNs) includes 4 members: IFN-λ1, 2, 3, and 4, and all 4 of these proteins signal through the same heterodimeric receptor complex: IFN-λR1 plus IL-10R2. Throughout the past 20 years, much has been learned about the IFN-λ family and the important role of these cytokines in antiviral responses against viruses such as hepatitis C virus, influenza A virus, and SARS-CoV-2. This special issue of the (JICR) features a group of new reports that highlight recent developments regarding various aspects of IFN-λ-mediated responses. Many of these reports were first presented during the Interferon Lambda 2022 Satellite Meeting after the "Cytokines 2022" meeting in Hawaii. These articles underscore the fact that our understanding of the IFN-λ family continues to evolve and remains a critical subject area for additional future research.
自干扰素 λ (IFN-λ) 家族最初被发现（Kotenko 等人，2003 年；Sheppard 等人，2003 年）以来，已经过去了 20 年，随后又发现了 IFN-λ4（Prokunina-Olsson 等人，2013 年）。IFN-λ 家族（III 型干扰素）包括 4 种成员：IFN-λ1、2、3 和 4，这 4 种蛋白都通过相同的异二聚体受体复合物发出信号：IFN-λR1 加 IL-10R2。在过去的 20 年里，人们对 IFN-λ 家族及其在抗病毒反应中的重要作用有了更多的了解，这些细胞因子可以对抗丙型肝炎病毒、甲型流感病毒和 SARS-CoV-2 等病毒。本期《干扰素与细胞因子研究杂志》（JICR）的一个特刊收录了一组新的报告，重点介绍了 IFN-λ 介导的反应的各个方面的最新进展。这些报告中的许多都是在夏威夷举行的“细胞因子 2022”会议之后的 IFN-λ 2022 卫星会议上首次提出的。这些文章强调了一个事实，即我们对 IFN-λ 家族的理解仍在不断发展，并且仍然是未来进一步研究的关键领域。
