Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J Interferon Cytokine Res. 2023 Sep;43(9):363-369. doi: 10.1089/jir.2023.0037. Epub 2023 Jun 8.
Type III interferon, or interferon lambda (IFNλ), was discovered 20 years ago and has been studied primarily for its role in combatting viral infections. However, it is also induced in response to certain bacterial infections but its roles and effects in this context are relatively poorly understood. In this mini review, we discuss the roles of IFNλ signaling in bacterial infections, highlighting its deleterious or protective effects for different infections. We also discuss a couple of recent studies showing that some bacteria possess defense mechanisms against the effects of IFNλ. We hope that this review will spur further investigation into the roles of IFNλ in the context of bacterial infections and will promote considerations of its therapeutic potential for these infections.
III 型干扰素，又称干扰素 λ（IFNλ），于 20 年前被发现，主要因其在抗病毒感染方面的作用而被研究。然而，IFNλ 也会在受到某些细菌感染时被诱导产生，但它在这种情况下的作用和影响还相对不太清楚。在这篇小型综述中，我们讨论了 IFNλ 信号在细菌感染中的作用，强调了它对不同感染的有害或保护作用。我们还讨论了最近的几项研究，表明一些细菌具有针对 IFNλ 作用的防御机制。我们希望这篇综述将进一步推动 IFNλ 在细菌感染背景下的作用的研究，并促进考虑其在这些感染中的治疗潜力。
