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Co-pathology may impact outcomes of amyloid-targeting treatments: clinicopathological results from two patients treated with aducanumab.

作者信息

VandeVrede Lawren, La Joie Renaud, Horiki Sheena, Mundada Nidhi S, Koestler Mary, Hwang Ji-Hye, Ljubenkov Peter A, Rojas Julio C, Rabinovici Gil D, Boxer Adam L, Seeley William W

机构信息

Department of Neurology, Memory and Aging Center, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.

Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.

出版信息

Acta Neuropathol. 2023 Nov;146(5):777-781. doi: 10.1007/s00401-023-02631-8. Epub 2023 Sep 19.

DOI:10.1007/s00401-023-02631-8
PMID:37725166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10564667/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b57/10564667/e146b0f91c33/401_2023_2631_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b57/10564667/9faeed833ddd/401_2023_2631_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b57/10564667/b141a5ed5fd1/401_2023_2631_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b57/10564667/e146b0f91c33/401_2023_2631_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b57/10564667/9faeed833ddd/401_2023_2631_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b57/10564667/b141a5ed5fd1/401_2023_2631_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b57/10564667/e146b0f91c33/401_2023_2631_Fig3_HTML.jpg

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Lecanemab in Early Alzheimer's Disease.早期阿尔茨海默病中的lecanemab
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Alzheimer disease neuropathology in a patient previously treated with aducanumab.阿杜卡努单抗治疗后的阿尔茨海默病患者的神经病理学。
Neuroimage Clin. 2025 Mar 10;46:103765. doi: 10.1016/j.nicl.2025.103765.
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Capillary basal lamina in human brain and spinal cord has fibrillar collagen type I and type III: Ignorance may not be bliss.人类大脑和脊髓中的毛细血管基膜含有I型和III型纤维状胶原蛋白:无知可能并非幸福。
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