Pediatrics College, Guangzhou Medical University, Guangzhou, China.
The First Clinical College, Chongqing Medical University, Chongqing, China.
Int J Environ Health Res. 2024 Jun;34(6):2441-2450. doi: 10.1080/09603123.2023.2253753. Epub 2023 Sep 19.
Copper is an indispensable trace element in metabolism. This study aimed to investigate the relationship between copper and reproductive health, and possibly provide new insights for diagnosis and treatment. This study was based on data extracted from the NHANES database (2013-2014 and 2015-2016). The -test, ANOVA, Chi-square test, multiple linear regression, and restricted cubic spline analysis were used. Serum copper levels were significantly higher in women with gestational diabetes than in those without gestational diabetes ( = 0.0150). Women with higher copper levels and smoking habits tended to deliver overweight babies ( = 0.028). Women with diabetes had higher serum copper and were prone to deliver overweight babies ( = 0.024). Serum copper levels showed a positive relationship with sex hormone-binding globulin (SHBG) levels ( < 0.0001). In this study, serum copper levels were found to be associated with reproductive health in women. Further studies are required to draw causal inferences.
铜是新陈代谢中不可或缺的微量元素。本研究旨在探讨铜与生殖健康的关系，为诊断和治疗提供新的思路。本研究基于 NHANES 数据库（2013-2014 年和 2015-2016 年）中的数据。采用检验、方差分析、卡方检验、多元线性回归和限制性立方样条分析。与无妊娠糖尿病的女性相比，患有妊娠糖尿病的女性血清铜水平明显升高（=0.0150）。血清铜水平较高且有吸烟习惯的女性更容易生出超重婴儿（=0.028）。患有糖尿病的女性血清铜水平较高，容易生出超重婴儿（=0.024）。血清铜水平与性激素结合球蛋白（SHBG）水平呈正相关（<0.0001）。本研究发现，女性血清铜水平与生殖健康有关。需要进一步的研究来得出因果关系。
