Department of Psychiatry, Wuhan Mental Health Center, No. 89, Gongnongbing Road, Wuhan, Hubei Province, China.
Wuhan Hospital for Psychotherapy, Wuhan, China.
Sci Rep. 2023 Sep 19;13(1):15496. doi: 10.1038/s41598-023-42720-y.
Major depressive disorder (MDD) is a common and socially burdensome psychiatric disorder with a causal and complex relationship with metabolic syndrome (MetS), which is often co-morbid. However, the prevalence and risk factors for MetS in patients with MDD are inconclusive. The purpose of this study is to investigate the prevalence and factors influencing MetS in first hospitalization MDD patients. A total of 981 MDD patients were included. Sociodemographic and general clinical data were collected from the patients, while metabolism-related parameters were also measured, and psychological symptoms were assessed. Our study found that the prevalence of MetS in the study population was 9.68%. MDD patients with MetS had higher levels of metabolism-related parameters and more severe psychological symptoms. We identified risk factors for MetS and its severity separately: age of onset of MDD, more severe depressive symptoms, and higher thyroid stimulating hormone (TSH) levels were risk factors for the development of MetS, whereas higher TSH levels were risk factors for the severity of MetS. Our results suggest that MetS is not highly prevalent in MDD patients, but certain risk factors may increase its likelihood and severity, and that these findings could be beneficial for clinical intervention and care of MetS.
重度抑郁症（MDD）是一种常见的、给社会带来沉重负担的精神疾病，它与代谢综合征（MetS）有着因果关系和复杂的关系，且常常并发。然而，MDD 患者代谢综合征的患病率和危险因素尚无定论。本研究旨在探讨首次住院 MDD 患者代谢综合征的患病率及影响因素。共纳入 981 例 MDD 患者。从患者那里收集人口统计学和一般临床数据，同时测量与代谢相关的参数，并评估心理症状。我们的研究发现，该研究人群中代谢综合征的患病率为 9.68%。患有代谢综合征的 MDD 患者的代谢相关参数水平更高，心理症状更严重。我们分别确定了代谢综合征及其严重程度的危险因素：MDD 的发病年龄、更严重的抑郁症状和更高的促甲状腺激素（TSH）水平是代谢综合征发展的危险因素，而更高的 TSH 水平是代谢综合征严重程度的危险因素。我们的研究结果表明，代谢综合征在 MDD 患者中并不高发，但某些危险因素可能会增加其发生和严重程度，这些发现有助于代谢综合征的临床干预和护理。
