Li Lu, Xiong Ling, Liu Zhihua, Zhang Lin
Department of Psychiatry, Wuhan Mental Health Center, Wuhan, China.
Department of Anesthesiology, The Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, China.
PLoS One. 2024 Dec 4;19(12):e0313629. doi: 10.1371/journal.pone.0313629. eCollection 2024.
Major depressive disorder (MDD) and metabolic syndrome (MetS) are significant health challenges, with distinct gender-specific manifestations. This suggests that the clinical presentation of MetS within the MDD cohort may also vary by gender. The objective of this study is to explore these gender-specific clinical patterns in the co-occurrence of MetS among hospitalized MDD patients, thereby offering insights and guidance for targeted interventions aimed at managing MetS in this demographic. The study included 1,281 first hospitalization MDD patients. Data were collected on socio-demographic characteristics and general clinical profiles. Metabolic parameters, routine biochemical markers, and psychological symptoms were measured and analyzed. The prevalence of MetS was 8.21% in male patients and 10.34% in female patients, with no significant difference between genders. Gender-specific risk factors were identified: in males, age and anxiety symptoms were significant predictors of MetS, while in females, age at onset and married were linked to the development of MetS. Additionally, MetS severity was influenced by age at onset in males and by both age at onset and married in females. This study found no gender-specific prevalence of MetS in hospitalized MDD patients. However, gender-specific factors influencing MetS development and severity highlight the need for focused management in older, married females and older males with high anxiety symptoms.
重度抑郁症（MDD）和代谢综合征（MetS）是重大的健康挑战，具有明显的性别特异性表现。这表明在MDD队列中，MetS的临床表现可能也因性别而异。本研究的目的是探讨住院MDD患者中MetS共病时这些性别特异性的临床模式，从而为针对该人群管理MetS的靶向干预提供见解和指导。该研究纳入了1281例首次住院的MDD患者。收集了社会人口学特征和一般临床资料的数据。对代谢参数、常规生化指标和心理症状进行了测量和分析。男性患者中MetS的患病率为8.21%，女性患者为10.34%，性别之间无显著差异。确定了性别特异性危险因素：在男性中，年龄和焦虑症状是MetS的显著预测因素，而在女性中，发病年龄和婚姻状况与MetS的发生有关。此外，MetS的严重程度在男性中受发病年龄影响，在女性中受发病年龄和婚姻状况两者影响。本研究发现住院MDD患者中MetS不存在性别特异性患病率。然而，影响MetS发生和严重程度的性别特异性因素凸显了对年龄较大、已婚的女性以及焦虑症状严重的老年男性进行重点管理的必要性。
