• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
[Questions and Answers in Lung Cancer].[肺癌问答]
Open Respir Arch. 2023 Sep 1;5(3):100264. doi: 10.1016/j.opresp.2023.100264. eCollection 2023 Jul-Sep.
2
Treatment of stage I and II non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.Ⅰ期和Ⅱ期非小细胞肺癌的治疗:肺癌的诊断和管理,第 3 版:美国胸科医师学会循证临床实践指南。
Chest. 2013 May;143(5 Suppl):e278S-e313S. doi: 10.1378/chest.12-2359.
3
Current status and future perspectives on immunotherapy in neoadjuvant therapy of resectable non-small cell lung cancer.可切除非小细胞肺癌新辅助治疗中免疫治疗的现状和未来展望。
Asia Pac J Clin Oncol. 2022 Aug;18(4):335-343. doi: 10.1111/ajco.13665. Epub 2021 Nov 23.
4
Tissue diagnosis of suspected lung cancer: selecting between bronchoscopy, transthoracic needle aspiration, and resectional biopsy.疑似肺癌的组织诊断:在支气管镜检查、经胸针吸活检和切除活检之间进行选择。
Respir Care Clin N Am. 2003 Mar;9(1):51-76. doi: 10.1016/s1078-5337(02)00083-7.
5
Long-term follow-up study of a population-based 1996-1998 mass screening programme for lung cancer using mobile low-dose spiral computed tomography.一项基于人群的1996 - 1998年使用移动低剂量螺旋计算机断层扫描进行肺癌大规模筛查项目的长期随访研究。
Lung Cancer. 2007 Dec;58(3):329-41. doi: 10.1016/j.lungcan.2007.06.022. Epub 2007 Aug 6.
6
Neoadjuvant Immunotherapy Combined with Chemotherapy for Local Advanced Non-Small-Cell Lung Cancer in a Patient with a History of Breast Cancer: A Case Report.新辅助免疫治疗联合化疗治疗乳腺癌病史局部晚期非小细胞肺癌 1 例报告。
Curr Oncol. 2022 Aug 29;29(9):6203-6210. doi: 10.3390/curroncol29090487.
7
The effect of direct referral for fast CT scan in early lung cancer detection in general practice. A clinical, cluster-randomised trial.在全科医疗中,直接转诊进行快速CT扫描对早期肺癌检测的效果。一项临床、整群随机试验。
Dan Med J. 2015 Mar;62(3).
8
Overview of resistance to systemic therapy in patients with breast cancer.乳腺癌患者全身治疗耐药概述。
Adv Exp Med Biol. 2007;608:1-22. doi: 10.1007/978-0-387-74039-3_1.
9
Are segmentectomy and lobectomy comparable in terms of curative intent for early stage non-small cell lung cancer?在早期非小细胞肺癌的治疗意图方面,肺段切除术和肺叶切除术具有可比性吗?
Gen Thorac Cardiovasc Surg. 2020 Jul;68(7):703-706. doi: 10.1007/s11748-019-01219-y. Epub 2019 Nov 6.
10
Pretherapeutic evaluation of patients with upper gastrointestinal tract cancer using endoscopic and laparoscopic ultrasonography.使用内镜超声和腹腔镜超声对上消化道癌患者进行治疗前评估。
Dan Med J. 2012 Dec;59(12):B4568.

引用本文的文献

1
A Thorough Review of the Clinical Applications of Artificial Intelligence in Lung Cancer.人工智能在肺癌临床应用的全面综述
Cancers (Basel). 2025 Mar 4;17(5):882. doi: 10.3390/cancers17050882.
2
Outcomes and Survival for Early-Stage Non-Small Cell Lung Cancer Following Wedge Resection or Lobectomy: A Propensity Score-Matched Analysis Using a Novel Peruvian Registry.楔形切除术或肺叶切除术后早期非小细胞肺癌的结局与生存情况:一项使用新型秘鲁登记系统的倾向评分匹配分析
J Chest Surg. 2024 Nov 5;57(6):501-510. doi: 10.5090/jcs.24.029. Epub 2024 Aug 8.

本文引用的文献

1
A novel, accurate, and non-invasive liquid biopsy test to measure cellular immune responses as a tool to diagnose early-stage lung cancer: a clinical trials study.一种新型、准确、无创的液体活检检测方法,用于测量细胞免疫反应,作为诊断早期肺癌的工具:一项临床试验研究。
Respir Res. 2023 Feb 14;24(1):52. doi: 10.1186/s12931-023-02358-w.
2
Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer.肺段或亚肺叶切除术治疗外周型ⅠA 期非小细胞肺癌。
N Engl J Med. 2023 Feb 9;388(6):489-498. doi: 10.1056/NEJMoa2212083.
3
Characterizing microbiota and metabolomics analysis to identify candidate biomarkers in lung cancer.表征微生物群和代谢组学分析以鉴定肺癌中的候选生物标志物。
Front Oncol. 2022 Nov 15;12:1058436. doi: 10.3389/fonc.2022.1058436. eCollection 2022.
4
Association between imaging surveillance frequency and outcomes following surgical treatment of early-stage lung cancer.手术后早期肺癌影像学监测频率与结果的关系。
J Natl Cancer Inst. 2023 Mar 9;115(3):303-310. doi: 10.1093/jnci/djac208.
5
Multidimensional Cell-Free DNA Fragmentomic Assay for Detection of Early-Stage Lung Cancer.多维游离细胞 DNA 片段组学分析检测早期肺癌。
Am J Respir Crit Care Med. 2023 May 1;207(9):1203-1213. doi: 10.1164/rccm.202109-2019OC.
6
International expert consensus on immunotherapy for early-stage non-small cell lung cancer.早期非小细胞肺癌免疫治疗的国际专家共识
Transl Lung Cancer Res. 2022 Sep;11(9):1742-1762. doi: 10.21037/tlcr-22-617.
7
Plasma-first: accelerating lung cancer diagnosis and molecular profiling through liquid biopsy.血浆优先:通过液体活检加速肺癌诊断和分子分析
Ther Adv Med Oncol. 2022 Sep 20;14:17588359221126151. doi: 10.1177/17588359221126151. eCollection 2022.
8
Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB-IIIA non-small-cell lung cancer (PEARLS/KEYNOTE-091): an interim analysis of a randomised, triple-blind, phase 3 trial.帕博利珠单抗对比安慰剂作为完全切除的 IB 期-IIIA 期非小细胞肺癌的辅助治疗(PEARLS/KEYNOTE-091):一项随机、三盲、III 期试验的中期分析。
Lancet Oncol. 2022 Oct;23(10):1274-1286. doi: 10.1016/S1470-2045(22)00518-6. Epub 2022 Sep 12.
9
Role of the Microbiota in Lung Cancer: Insights on Prevention and Treatment.微生物群在肺癌中的作用:预防和治疗的新视角。
Int J Mol Sci. 2022 May 30;23(11):6138. doi: 10.3390/ijms23116138.
10
Spanish Society of Thoracic Surgery (SECT) consensus document. Long-term follow-up for operated patients with lung cancer.西班牙胸外科学会 (SECT) 共识文件。肺癌手术患者的长期随访。
Cir Esp (Engl Ed). 2022 Jun;100(6):320-328. doi: 10.1016/j.cireng.2022.05.024. Epub 2022 May 25.

[肺癌问答]

[Questions and Answers in Lung Cancer].

作者信息

Manzano Carlos, Fuentes-Martín Álvaro, Zuil Maria, Gil Barturen Mariana, González Jessica, Cilleruelo-Ramos Ángel

机构信息

Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lérida, España.

Servicio de Cirugía Torácica, Hospital Clínico Universitario de Valladolid, Universidad de Valladolid, Valladolid, España.

出版信息

Open Respir Arch. 2023 Sep 1;5(3):100264. doi: 10.1016/j.opresp.2023.100264. eCollection 2023 Jul-Sep.

DOI:10.1016/j.opresp.2023.100264
PMID:37727151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10505677/
Abstract

Over the past 2 decades, scientific evidence has strongly supported the use of low-radiation dose chest computed tomography (CT) as a screening technique for lung cancer. This approach has resulted in a significant reduction in mortality rates by enabling the detection of early-stage lung cancer amenable to potentially curative treatments. Regarding diagnosis, there are also novel methods under study, such as liquid biopsy, identification of the pulmonary microbiome, and the use of artificial intelligence techniques, which will play a key role in the near future. At present, there is a growing trend towards less invasive surgical procedures, such as segmentectomy, as an alternative to lobectomy. This procedure is based on 2 recent clinical trials conducted on peripheral tumors measuring less than 2 cm. Although these approaches have demonstrated comparable survival rates, there remains controversy due to uncertainties surrounding recurrence rates and functional capacity preservation. With regard to adjuvant therapy, immunotherapy, either as a monotherapy or in conjunction with chemotherapy, has shown encouraging results in resectable stages of locally advanced lung cancer, demonstrating complete pathologic responses and improved overall survival.After surgery treatment, despite the lack of solid evidence for long-term follow-up of these patients, clinical practice recommends periodic CT scans during the early years.In conclusion, there have been significant advances in lung cancer that have improved diagnostic techniques using new technologies and screening programs. Furthermore, the treatment of lung cancer is increasingly personalized, resulting in an improvement in the survival of patients.

摘要

在过去20年中,科学证据有力地支持了使用低辐射剂量胸部计算机断层扫描(CT)作为肺癌筛查技术。这种方法通过能够检测出适合进行潜在治愈性治疗的早期肺癌,使死亡率显著降低。在诊断方面,也有一些新方法正在研究中,如液体活检、肺部微生物群的鉴定以及人工智能技术的应用,这些在不久的将来将发挥关键作用。目前,作为肺叶切除术的替代方法,诸如肺段切除术等侵入性较小的外科手术有增加的趋势。该手术基于最近对直径小于2厘米的周围型肿瘤进行的两项临床试验。尽管这些方法已显示出相当的生存率,但由于复发率和功能保留方面存在不确定性,仍存在争议。关于辅助治疗,免疫疗法无论是作为单一疗法还是与化疗联合使用,在局部晚期肺癌的可切除阶段都显示出令人鼓舞的结果,表现出完全的病理反应并改善了总生存期。手术后,尽管缺乏对这些患者进行长期随访的确凿证据,但临床实践建议在早期进行定期CT扫描。总之,肺癌领域已取得重大进展,利用新技术和筛查项目改进了诊断技术。此外,肺癌治疗越来越个性化,从而提高了患者的生存率。