补充左旋肉碱对成年人血脂的影响：干预性荟萃分析的伞状荟萃分析
The effect of L-carnitine supplementation on lipid profile in adults: an umbrella meta-analysis on interventional meta-analyses.
作者信息
Musazadeh Vali, Alinejad Hanie, Esfahani Niloofar Kouhi, Kavyani Zeynab, Keramati Majid, Roshanravan Neda, Mosharkesh Erfan, Dehghan Parvin
机构信息
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Front Nutr. 2023 Sep 4;10:1214734. doi: 10.3389/fnut.2023.1214734. eCollection 2023.
INTRODUCTION
Previous meta-analyses investigating the therapeutic effects of L-carnitine on lipid profiles have demonstrated inconsistent results. The present umbrella meta-analysis aimed to investigate the impact of efficacy of L-carnitine on lipid profiles in adults.
METHODS
Databases including PubMed, Scopus, and Embase, Web of Science, and Google Scholar were searched up to June 2023. Meta-analysis was performed using a random-effects model.
RESULTS
Our results from thirteen meta-analyses indicated that L-carnitine supplementation significantly total cholesterol (TC) (ES = -1.05 mg/dL, 95% CI: -1.71, -0.39; = 0.002), triglycerides (TG) (ES = -2.51 mg/dL; 95% CI: -3.62, -1.39, < 0.001), and low-density lipoprotein-cholesterol (LDL-C) (ES = -4.81 mg/dL; 95% CI: -6.04, -3.59; p < 0.001). It also increased high-density lipoprotein-cholesterol (HDL-C) (ES: 0.66 mg/dL, 95% CI: 0.20, 1.12, = 0.005) levels.
CONCLUSION
The present umbrella meta-analysis suggests supplementation with L-carnitine in a dosage of more than 2 g/day can improve lipid profile. Thus, L-carnitine supplementation can be recommended as an adjuvant anti-hyperlipidemic agent.
引言
先前关于左旋肉碱对血脂影响的荟萃分析结果并不一致。本伞状荟萃分析旨在研究左旋肉碱对成年人血脂的疗效影响。
方法
检索了截至2023年6月的数据库，包括PubMed、Scopus、Embase、Web of Science和谷歌学术。采用随机效应模型进行荟萃分析。
结果
我们对13项荟萃分析的结果表明，补充左旋肉碱可显著降低总胆固醇（TC）（效应量= -1.05mg/dL，95%置信区间：-1.71，-0.39；p = 0.002）、甘油三酯（TG）（效应量= -2.51mg/dL；95%置信区间：-3.62，-1.39，p < 0.001）和低密度脂蛋白胆固醇（LDL-C）（效应量= -4.81mg/dL；95%置信区间：-6.04，-3.59；p < 0.001）。它还能提高高密度脂蛋白胆固醇（HDL-C）（效应量：0.66mg/dL，95%置信区间：0.20，1.12，p = 0.005）水平。
结论
本伞状荟萃分析表明，每天补充超过2克的左旋肉碱可以改善血脂状况。因此，左旋肉碱补充剂可作为辅助抗高血脂药物推荐使用。
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