Asbaghi Omid, Kashkooli Sara, Amini Mohammad Reza, Shahinfar Hossein, Djafarian Kurosh, Clark Cain C T, Shab-Bidar Sakineh
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
J Cardiovasc Thorac Res. 2020;12(4):246-255. doi: 10.34172/jcvtr.2020.43. Epub 2020 Sep 7.
This meta-analysis was performed to assess the effect of L-carnitine supplementation on lipid profile. A systematic search were conducted in PubMed and Scopus to identify randomized clinical trials (RCTs) which evaluated the effects of L-carnitine on lipid profile. Pooled effect sizes were measured using random-effect model (Dersimonian-Laird). Meta-analysis showed that L-carnitine supplementation significantly reduced total cholesterol (TC) (weighted mean difference [WMD]: -8.17 mg/dL; 95% CI,-14.68 to -1.65, I=52.2%, = 0.041). Baseline level of TC was a source of heterogeneity, with a greater effect in studies with a baseline level of more than 200 mg/d (WMD: -11.93 mg/dL; 95% CI, -20.80 to-3.05). L-carnitine also significantly decreased low-density lipoprotein-cholesterol (LDL-C) (WMD:-5.22 mg/dL; 95% CI, -9.54 to -0.91, I=66.7%, = 0.010), and LDL-C level <100 mg/dL), trial duration,and L-carnitine dosage were potential sources of heterogeneity. L-carnitine supplementation appeared to have no significant effect on high-density lipoprotein-cholesterol (HDL-C) (WMD: -0.51 mg/dL;95% CI, -2.45 to 1.44) and triglyceride (TG) (WMD: 2.80 mg/dL; 95% CI, -8.09 to 13.69). This meta-analysisrevealed that L-carnitine may have favorable effects on lipid profile, especially LDL-C and TC. However, further RCTs are needed to confirm the veracity of these results, particularly among hyperlipidemic patients.
本荟萃分析旨在评估补充左旋肉碱对血脂谱的影响。在PubMed和Scopus中进行了系统检索，以识别评估左旋肉碱对血脂谱影响的随机临床试验（RCT）。使用随机效应模型（德西蒙尼安-莱尔德法）测量合并效应量。荟萃分析表明，补充左旋肉碱可显著降低总胆固醇（TC）（加权平均差[WMD]：-8.17mg/dL；95%置信区间，-14.68至-1.65，I² = 52.2%，P = 0.041）。TC的基线水平是异质性的一个来源，在基线水平超过200mg/dL的研究中效应更大（WMD：-11.93mg/dL；95%置信区间，-20.80至-3.05）。左旋肉碱还显著降低了低密度脂蛋白胆固醇（LDL-C）（WMD：-5.22mg/dL；95%置信区间，-9.54至-0.91，I² = 66.7%，P = 0.010），而LDL-C水平<100mg/dL、试验持续时间和左旋肉碱剂量是潜在的异质性来源。补充左旋肉碱似乎对高密度脂蛋白胆固醇（HDL-C）（WMD：-0.51mg/dL；95%置信区间，-2.45至1.44）和甘油三酯（TG）（WMD：2.80mg/dL；95%置信区间，-8.09至13.69）没有显著影响。本荟萃分析表明，左旋肉碱可能对血脂谱有有益影响，尤其是对LDL-C和TC。然而，需要进一步的随机对照试验来证实这些结果的真实性，特别是在高脂血症患者中。
