补充合生元对人体测量和血脂参数的影响：伞状荟萃分析的结果
Effects of synbiotics supplementation on anthropometric and lipid profile parameters: Finding from an umbrella meta-analysis.
作者信息
Musazadeh Vali, Mohammadi Anilou Maryam, Vajdi Mahdi, Karimi Arash, Sedgh Ahrabi Sana, Dehghan Parvin
机构信息
Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Emergency Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Front Nutr. 2023 Feb 23;10:1121541. doi: 10.3389/fnut.2023.1121541. eCollection 2023.
INTRODUCTION
Several systematic reviews and meta-analyses have been carried out to assess the impact of synbiotics on lipid profiles and anthropometric parameters. In this regard, an umbrella meta-analysis was performed to provide a more accurate view of the overall impacts of synbiotic supplementation on lipid profile and anthropometric parameters.
METHODS
Databases such as PubMed, Scopus, Embase, Web of Science, and Google Scholar were searched for this study from inception to January 2022. A random-effects model was applied to evaluate the effects of synbiotic supplementation on lipid profile and anthropometric parameters. The methodological quality of eligible articles was evaluated using the AMSTAR2 questionnaire. The GRADE approach was used to evaluate the overall certainty of the evidence in the meta-analyses.
RESULTS
Meta-analyses of 17 studies revealed significant decreases in body mass index (BMI) (ES: -0.13 kg/m2; 95% CI: -0.19, -0.06, < 0.001, I = 0.0%, = 0.870), BW (ES: -1.30 kg; 95% CI: -2.19, -0.41, = 0.004, I = 88.9%, < 0.001), waist circumference (WC) (ES: -1.80 cm; 95% CI: -3.26, -0.34, = 0.016, I = 94.1%, < 0.001), low-density lipoprotein cholesterol (LDL-C) (ES: -2.81 mg/dl; 95% CI: -3.90, -1.72, < 0.001, I = 95.1%, < 0.001), total cholesterol (TC) (ES = -2.24 mg/dl; 95% CI: -3.18, -1.30, < 0.001, I = 94.5%, < 0.001), and triglyceride (TG) (ES: -0.43 mg/dl; 95% CI: -0.79, -0.07, = 0.019, I = 78.0%, < 0.001) but not high-density lipoprotein cholesterol (HDL-C) (ES: 0.23 mg/dl; 95% CI: -0.11, 0.56, = 0.193, I = 45.2%, = 0.051) following synbiotic supplementation.
DISCUSSION
The present umbrella meta-analysis suggests synbiotic supplementation can slightly improve lipid profile and anthropometric indices and might be a therapeutic option for obesity and its related disorders.
SYSTEMATIC REVIEW REGISTRATION
www.crd.york.ac.uk/prospero, identifier CRD42022304376.
引言
已经进行了多项系统评价和荟萃分析来评估合生元对血脂谱和人体测量参数的影响。在此方面，进行了一项汇总荟萃分析，以更准确地了解补充合生元对血脂谱和人体测量参数的总体影响。
方法
本研究检索了从数据库建立至2022年1月的PubMed、Scopus、Embase、Web of Science和谷歌学术等数据库。应用随机效应模型来评估补充合生元对血脂谱和人体测量参数的影响。使用AMSTAR2问卷评估符合条件文章的方法学质量。采用GRADE方法评估荟萃分析中证据的总体确定性。
结果
对17项研究的荟萃分析显示，补充合生元后，体重指数（BMI）（效应量：-0.13kg/m²；95%置信区间：-0.19，-0.06，P<0.001，I²=0.0%，τ²=0.870）、体重（BW）（效应量：-1.30kg；95%置信区间：-2.19，-0.41，P=0.004，I²=88.9%，P<0.001）、腰围（WC）（效应量：-1.80cm；95%置信区间：-3.26，-0.34，P=0.016，I²=94.1%，P<0.001）、低密度脂蛋白胆固醇（LDL-C）（效应量：-2.81mg/dl；95%置信区间：-3.90，-1.72，P<0.001，I²=95.1%，P<0.001）、总胆固醇（TC）（效应量=-2.24mg/dl；95%置信区间：-3.18，-1.30，P<0.001，I²=94.5%，P<0.001）和甘油三酯（TG）（效应量：-0.43mg/dl；95%置信区间：-0.79，-0.07，P=0.019，I²=78.0%，P<0.001）均显著降低，但高密度脂蛋白胆固醇（HDL-C）未降低（效应量：0.23mg/dl；95%置信区间：-0.11，0.56，P=0.193，I²=45.2%，P=0.051）。
讨论
本汇总荟萃分析表明，补充合生元可略微改善血脂谱和人体测量指标，可能是肥胖及其相关疾病的一种治疗选择。
系统评价注册
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