Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, China.
Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.
JMIR Public Health Surveill. 2023 Sep 20;9:e49968. doi: 10.2196/49968.
Nasopharyngeal cancer (NPC) is one of the most common head and neck cancers.
This study describes the global epidemiological profiles of NPC incidence and mortality in 185 countries in 2020 and the projected burden in 2040.
The estimated numbers of NPC cases and deaths were retrieved from the GLOBOCAN 2020 data set. Age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were calculated using the world standard. The future number of NPC cases and deaths by 2040 were estimated based on global demographic projections.
Globally, approximately 133,354 cases and 80,008 deaths from NPC were estimated in 2020 corresponding to ASIRs and ASMRs of 1.5 and 0.9 per 100,000 person-years, respectively. The largest numbers of both global cases and deaths from NPC occurred in Eastern Asia (65,866/133,354, 49.39% and 36,453/80,008, 45.56%, respectively), in which China contributed most to this burden (62,444/133,354, 46.82% and 34,810/80,008, 43.50%, respectively). The ASIRs and ASMRs in men were approximately 3-fold higher than those in women. Incidence rates varied across world regions, with the highest ASIRs for both men and women detected in South-Eastern Asia (7.7 and 2.5 per 100,000 person-years, respectively) and Eastern Asia (3.9 and 1.5 per 100,000 person-years, respectively). The highest ASMRs for both men and women were found in South-Eastern Asia (5.4 and 1.5 per 100,000 person-years, respectively). By 2040, the annual number of cases and deaths will increase to 179,476 (46,122/133,354, a 34.58% increase from the year 2020) and 113,851 (33,843/80,008, a 42.29% increase), respectively.
Disparities in NPC incidence and mortality persist worldwide. Our study highlights the urgent need to develop and accelerate NPC control initiatives to tackle the NPC burden in certain regions and countries (eg, South-Eastern Asia, China).
鼻咽癌（NPC）是最常见的头颈部癌症之一。
本研究描述了 2020 年全球 185 个国家 NPC 发病率和死亡率的全球流行病学特征，并预测了 2040 年的疾病负担。
从 GLOBOCAN 2020 数据集检索 NPC 病例和死亡的估计数。使用世界标准计算年龄标准化发病率（ASIR）和年龄标准化死亡率（ASMR）。根据全球人口预测，估计 2040 年 NPC 病例和死亡的未来数量。
全球 2020 年 NPC 病例和死亡估计数分别为 133354 例和 80008 例，ASIR 和 ASMR 分别为 1.5 和 0.9/10 万。全球 NPC 病例和死亡人数最多的地区均为东亚（分别为 65866/133354，占 49.39%和 36453/80008，占 45.56%），其中中国占这一负担的最大比例（分别为 62444/133354，占 46.82%和 34810/80008，占 43.50%）。男性的 ASIR 和 ASMR 大约是女性的 3 倍。发病率在世界各地区有所不同，东南亚（男性和女性分别为 7.7 和 2.5/10 万）和东亚（男性和女性分别为 3.9 和 1.5/10 万）的 ASIR 最高。男性和女性的最高 ASMR 均出现在东南亚（分别为 5.4 和 1.5/10 万）。到 2040 年，每年的病例数和死亡数将分别增加到 179476（46122/133354，比 2020 年增加 34.58%）和 113851（33843/80008，比 2020 年增加 42.29%）。
全球 NPC 发病率和死亡率存在差异。我们的研究强调迫切需要制定和加速 NPC 控制计划，以解决某些地区和国家（例如东南亚、中国）的 NPC 负担。
