Topical flucytosine therapy for chronic recurrent Candida tropicalis infections.

Forty-one women with a culture-proven diagnosis of Candida tropicalis were treated with miconazole or clotrimazole cream topically or ketoconazole orally. In 15 patients the infection recurred or remained uncured. Five-fluorocytosine was compounded into a topical vaginal cream and applied nightly for seven nights. In 14 of the 15 patients the infection disappeared. One patient remains uncured.