Lebherz T B, Goldman L, Wiesmeier E, Mason D, Ford L C
Clin Ther. 1983;5(4):409-16.
In a double-blind clinical study, 93 patients with vulvovaginal candidiasis were randomly assigned to treatment with either clotrimazole (1%) or miconazole (2%) vaginal cream for seven days. The treatments were comparable in reducing the severity of presenting signs and symptoms. At one and four weeks posttherapy, negative vaginal cultures were found in 84.4% and 75.0%, respectively, of the clotrimazole-treated patients and in 85.4% and 74.5%, respectively, of the miconazole-treated patients. The incidences of recurrence/reinfection and treatment failures were comparable in the two groups. Treatment failures and recurrences/reinfections were not correlated with positive perianal cultures for Candida species. Patients using oral contraceptives had a higher incidence of positive vaginal cultures at four weeks posttherapy than did patients not using oral contraceptives or using other methods.
在一项双盲临床研究中，93例外阴阴道念珠菌病患者被随机分配接受克霉唑（1%）或咪康唑（2%）阴道乳膏治疗，为期7天。两种治疗方法在减轻现有体征和症状的严重程度方面具有可比性。治疗后1周和4周时，接受克霉唑治疗的患者中分别有84.4%和75.0%阴道培养结果为阴性，接受咪康唑治疗的患者中分别有85.4%和74.5%阴道培养结果为阴性。两组的复发/再感染率和治疗失败率相当。治疗失败以及复发/再感染与肛周念珠菌属培养阳性无关。使用口服避孕药的患者在治疗后4周时阴道培养阳性率高于未使用口服避孕药或使用其他避孕方法的患者。
