Itala J, di Paola G R, Gomez Rueda N, Perez Lloret I, Buquet R
J Reprod Med. 1986 Sep;31(9):836-8.
Nine cases of vulvar melanoma were studied: the histologic variants, depth of invasion and prognostic significance of these factors and of node involvement were analyzed. The histologic types were in situ melanoma (one case), superficial spreading melanoma (two cases) and nodular melanoma (six cases). The mean age of the patients was 64.9 years. Eight patients were treated with radical surgery and one with chemotherapy only. We found a good prognosis for in situ melanoma with free margins; a tendency for superficial spreading melanoma to recur, though it has a good prognosis when it does not exceed Clark level II; and an ominous prognosis for nodular melanoma, probably because of its late diagnosis.
对9例外阴黑色素瘤进行了研究：分析了组织学变异、浸润深度以及这些因素和淋巴结受累情况的预后意义。组织学类型包括原位黑色素瘤（1例）、浅表扩散性黑色素瘤（2例）和结节性黑色素瘤（6例）。患者的平均年龄为64.9岁。8例患者接受了根治性手术，1例仅接受了化疗。我们发现原位黑色素瘤切缘阴性时预后良好；浅表扩散性黑色素瘤有复发倾向，不过当其未超过克拉克二级时预后良好；而结节性黑色素瘤预后不佳，可能是因为诊断较晚。
