Vavra N, Seifert M, Czerwenka K, Pehamberger H, Kucera H, Weghaupt K
Ordinariat für gynäkologische Strahlentherapie, Universität Wien.
Geburtshilfe Frauenheilkd. 1991 May;51(5):379-82. doi: 10.1055/s-2007-1026162.
The present retrospective study includes 12 patients with melanoma of the vulva who underwent vulvectomy between 1977 and 1987. Six patients were less than 55 and 6 other patients more than 69 years old. Three women of the younger age group survived (31, 44 and 116 months, respectively), whereas three of them died of the tumour. In the patient group of over 69 years of age 4 patients died of the tumour, one patient did not appear for follow-up and one further patient died in the meantime. Nine patients suffered from deeply infiltrating tumours (Clark levels IV and V), 2 patients had a Clark level II tumour, and in one case the Clark level was unknown. Depth of infiltration correlated with the prognosis of disease, i.e. only one patient with deep tumour infiltration, but both patients with Clark level II tumours survived. Therefore, the importance of early diagnosis of melanoma of the vulva should be emphasized, and accurate inspection of the vulva should be indispensable in the course of routine gynaecological examination also in younger women.
本回顾性研究纳入了1977年至1987年间接受外阴切除术的12例外阴黑色素瘤患者。6例患者年龄小于55岁，另外6例患者年龄大于69岁。较年轻年龄组的3名女性存活（分别存活31、44和116个月），而其中3名死于肿瘤。在年龄超过69岁的患者组中，4例死于肿瘤，1例未前来随访，另有1例在此期间死亡。9例患者患有深度浸润性肿瘤（Clark分级IV级和V级），2例患者为Clark分级II级肿瘤，1例患者的Clark分级未知。浸润深度与疾病预后相关，即只有1例肿瘤深度浸润患者，但2例Clark分级II级肿瘤患者均存活。因此，应强调外阴黑色素瘤早期诊断的重要性，在年轻女性的常规妇科检查过程中，对外阴进行准确检查也必不可少。
