Polin D, Olson B, Bursian S, Lehning E
J Toxicol Environ Health. 1986;19(3):359-68. doi: 10.1080/15287398609530934.
Young chickens fed hexachlorobenzene (HCB) or pentachlorophenol (PCP) for 14 d at 10 ppm in the diet contained body burdens of 573 or 362 micrograms, respectively. These diets were withdrawn (d 0) and replaced for 21 d with diets containing 5% mineral oil (MO), or 5% colestipol (CO), a bile-acid-binding resin, or the chickens were restricted in feed intake to 50% of controls (50-RF), fed MO plus 50-RF, or CO plus 50-RF. Without any treatment during withdrawal, body burdens were reduced to 63% and 70% of the d 0 values for HCB and PCP, respectively. MO, CO, or 50-RF reduced body burdens of HCB to 37% of d 0 burdens, but the combination treatments with 50-RF reduced body burdens to 19% of d 0 values. PCP was at 35% of the d 0 burdens from 50-RF, while all other treatments had reduced body burdens to nondetectable amounts of less than 0.7 micrograms/bird by d 21 of withdrawal. Body fat was not reduced by mineral oil, but was reduced to some extent by CO, and was markedly reduced by 50-RF. 50-RF always reduced body burdens of PCP or HCB alone or in combination with MO or CO. These data are discussed in relationship to the nonbiliary excretion of xenobiotics.
给幼鸡饲喂含10 ppm六氯苯（HCB）或五氯苯酚（PCP）的日粮14天，其体内负荷分别为573或362微克。撤去这些日粮（第0天），并用含5%矿物油（MO）、或5%考来烯胺（CO，一种胆汁酸结合树脂）的日粮替代21天，或者将鸡的采食量限制为对照的50%（50-RF），饲喂MO加50-RF，或CO加50-RF。在撤料期间不进行任何处理，HCB和PCP的体内负荷分别降至第0天值的63%和70%。MO、CO或50-RF使HCB的体内负荷降至第0天负荷的37%，但50-RF的联合处理使体内负荷降至第0天值的19%。50-RF时PCP为第0天负荷的35%，而所有其他处理在撤料第21天时已将体内负荷降至不可检测水平，即低于0.7微克/只。矿物油未使体脂减少，但CO使其有所减少，50-RF使其显著减少。50-RF单独或与MO或CO联合使用时，总能降低PCP或HCB的体内负荷。本文结合外源性物质的非胆汁排泄对这些数据进行了讨论。
