Polin D, Lehning E, Pullen D, Bursian S, Leavitt R
J Toxicol Environ Health. 1985;16(2):243-54. doi: 10.1080/15287398509530737.
Egg- and meat-type chickens were fed diets containing 1 or 10 ppm of fireMaster (FF-1), a commercial mixture of polybrominated biphenyls (PBBs), predominantly 2,4,5,2',4',5'-hexabromobiphenyl (6BB-4) and 2,3,4,5,2',4',5'-heptabromobiphenyl (7BB-8). These congeners account for approximately 65 and 14%, respectively, of the total mix. In three experiments, colestipol hydrochloride, a bile acid-binding resin, and mineral oil, alone or in combination with restricted feeding, were examined as procedures to enhance the removal of the PBBs. The combination of 50% dietary restriction plus a 10% dietary concentration of colestipol or mineral oil reduced body burdens of PBBs about 70% within 21 d for chickens previously fed 10 ppm PBBs. The use of feed restriction, colestipol, or mineral oil produced only borderline effects for hastening withdrawal. Chickens not treated showed only a 3% loss of PBBs during the withdrawal period. Colestipol at 2.5% in the diet in combination with feed restriction was not consistently effective in removing body burdens of PBB from chickens previously fed 1 or 10 ppm PBBs, indicating a dose-response effect. Chickens previously fed 1 ppm eliminated up to 40% of the PBBs in 21 d without any treatment, as compared to the 3% loss occurring after feeding with 10-ppm concentrations.
蛋用型和肉用型鸡被喂食了含有1 ppm或10 ppm FireMaster（FF - 1）的日粮，FireMaster是一种多溴联苯（PBBs）的商业混合物，主要成分是2,4,5,2',4',5'-六溴联苯（6BB - 4）和2,3,4,5,2',4',5'-七溴联苯（7BB - 8）。这些同系物分别约占混合物总量的65%和14%。在三个实验中，研究了盐酸考来烯胺（一种胆汁酸结合树脂）和矿物油单独或与限饲联合使用，作为增强PBBs清除的方法。对于之前喂食10 ppm PBBs的鸡，50%的日粮限制加上日粮中10%浓度的考来烯胺或矿物油的组合，在21天内使PBBs的体内负担降低了约70%。限饲、考来烯胺或矿物油的使用对加速清除仅产生了临界效果。未处理的鸡在清除期内PBBs仅损失了3%。日粮中2.5%的考来烯胺与限饲联合使用，对于清除之前喂食1 ppm或10 ppm PBBs的鸡体内的PBBs负担并不总是有效，这表明存在剂量反应效应。之前喂食1 ppm的鸡在21天内无需任何处理可清除高达40%的PBBs，而喂食10 ppm浓度后PBBs损失3%。
