Lu Q H, Swierczek J S, Zhu X G, Greeley G H, Thompson J C
J Neurosci Res. 1986;16(3):553-9. doi: 10.1002/jnr.490160310.
This study compared the effects of bombesin given intracerebroventricularly and intravenously on circulating levels of gastrin, pancreatic polypeptide (PP), and cholecystokinin (CCK-33). Bilateral cannulas were implanted permanently into the lateral cerebral ventricles of five dogs. An intravenous (IV) bolus injection of bombesin (0.25 microgram/kg) significantly elevated circulating levels of gastrin, PP, and CCK-33. Vagotomy inhibited the release of PP that was induced by IV bombesin, but vagotomy did not affect gastrin and CCK-33 responses. Intracerebroventricular injection of bombesin (5.0 micrograms) significantly elevated circulating gastrin levels but did not affect circulating levels of CCK-33 and PP. Vagotomy did not alter gastrin release induced by intracerebroventricular injection of bombesin.
本研究比较了脑室内注射和静脉注射蛙皮素对胃泌素、胰多肽（PP）和胆囊收缩素（CCK - 33）循环水平的影响。将双侧套管永久性植入五只犬的侧脑室。静脉推注蛙皮素（0.25微克/千克）显著提高了胃泌素、PP和CCK - 33的循环水平。迷走神经切断术抑制了静脉注射蛙皮素诱导的PP释放，但迷走神经切断术不影响胃泌素和CCK - 33的反应。脑室内注射蛙皮素（5.0微克）显著提高了循环胃泌素水平，但不影响CCK - 33和PP的循环水平。迷走神经切断术未改变脑室内注射蛙皮素诱导的胃泌素释放。
