全小肠切除抑制了麻醉猫中蛙皮素刺激的胆囊收缩素和胰多肽释放。

Total small bowel resection inhibited bombesin-stimulated release of cholecystokinin and pancreatic polypeptide in anesthetized cats.

作者信息

Inoue K, Chowdhury P, Hosotani R, McKay D, Ami M, Rayford P L

机构信息

First Department of Surgery, Kyoto University, Japan.

出版信息

J Surg Res. 1989 Jul;47(1):87-91. doi: 10.1016/0022-4804(89)90052-8.

DOI:10.1016/0022-4804(89)90052-8

PMID:2739404

Abstract

In anesthetized cats, immunoreactive cholecystokinin (CCK), pancreatic polypeptide (PP), and gastrin were released in response to bombesin both before and after small bowel resection. Total small bowel resection significantly decreased bombesin-stimulated release of cholecystokinin and pancreatic polypeptide without affecting the release of gastrin. Integrated analysis showed that CCK, pancreatic polypeptide, and gastrin were released in significant quantities after small bowel resection. The results show that total small bowel resection caused significant inhibition of bombesin-stimulated release of cholecystokinin and pancreatic polypeptide; in contrast, gastrin release remained unaffected. The data further indicate that extra bowel sources of cholecystokinin exist in cats and the release of CCK from those sources occurred following bombesin stimulation.

摘要

在麻醉的猫中，无论小肠切除术前还是术后，蛙皮素均可引起免疫反应性胆囊收缩素（CCK）、胰多肽（PP）和胃泌素的释放。全小肠切除显著降低了蛙皮素刺激的胆囊收缩素和胰多肽的释放，但不影响胃泌素的释放。综合分析表明，小肠切除术后CCK、胰多肽和胃泌素大量释放。结果表明，全小肠切除导致蛙皮素刺激的胆囊收缩素和胰多肽释放受到显著抑制；相比之下，胃泌素释放未受影响。数据进一步表明，猫体内存在胆囊收缩素的肠外来源，并且这些来源的CCK在蛙皮素刺激后释放。