Department of Biomedical Engineering, Bangladesh University of Engineering and Technology (BUET), Dhaka 1205, Bangladesh.
Institute of Sustainability for Chemicals, Energy and Environment, A*STAR (Agency for Science, Technology and Research), Singapore 138634, Singapore.
Int J Biol Macromol. 2023 Dec 31;253(Pt 4):126868. doi: 10.1016/j.ijbiomac.2023.126868. Epub 2023 Sep 18.
In this study, olive oil nanoemulsion modified with xanthan gum and gum acacia was explored as a potential controlled topical delivery vehicle. Oil-in-water nanoemulsion formulated with optimized composition of olive oil, tween 80, and water was used as the drug carrier and further modified with gum. Effect of gum on nanoemulsion different physiochemical characteristics, stability, rheology, drug release and encapsulation efficiency were investigated. Results showed that developed nanoemulsion behaved as low viscosity Newtonian fluid and released 100 % drug within 6 h. Modification with xanthan and gum acacia had significantly improved formulation viscosity, drug encapsulation efficiency (>85 %) and controlled drug release up to 40 % with release pattern following Korsmeyer-Peppas model. Additionally, xanthan gum modified formulation exhibited shear thinning rheology by forming an extended network in the continuous phase, whereas gum acacia modified formulation behaved as Newtonian fluid at high shear rate (>200 s). Furthermore, xanthan gum modified formulations had improved zeta potential, stability, monodispersity, and hemocompatibility and showed high antibacterial activity against S. aureus than gum acacia modified formulations. These results indicate the higher potential of xanthan gum modified formulation as a topical delivery vehicle. Moreover, skin irritation test demonstrated the safety of developed formulations for topical application.
在这项研究中，研究了用黄原胶和阿拉伯胶改性的橄榄油纳米乳液，将其作为一种潜在的控制局部递药载体。以优化组成的橄榄油、吐温 80 和水制备的油包水纳米乳液作为药物载体，并进一步用胶改性。考察了胶对纳米乳液不同理化特性、稳定性、流变学、药物释放和包封效率的影响。结果表明，所开发的纳米乳液表现为低粘度牛顿流体，在 6 小时内释放 100%的药物。用黄原胶和阿拉伯胶改性显著提高了制剂的粘度、药物包封效率（>85%）和控制药物释放，释放模式符合 Korsmeyer-Peppas 模型，达到 40%。此外，黄原胶改性制剂在连续相中形成扩展网络，表现出剪切稀化流变学特性，而阿拉伯胶改性制剂在高剪切速率（>200s）下表现为牛顿流体。此外，黄原胶改性制剂具有更高的zeta 电位、稳定性、单分散性和血液相容性，对金黄色葡萄球菌的抗菌活性也高于阿拉伯胶改性制剂。这些结果表明，黄原胶改性制剂作为一种局部递药载体具有更高的潜力。此外，皮肤刺激性试验表明，所开发的制剂适用于局部应用。
