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新大陆而非旧大陆灵长类动物膀胱中的一种假定非胆碱能机制。

A putative non-cholinergic mechanism in urinary bladders of New but not Old World primates.

作者信息

Craggs M D, Rushton D N, Stephenson J D

出版信息

J Urol. 1986 Dec;136(6):1348-50. doi: 10.1016/s0022-5347(17)45335-3.

DOI:10.1016/s0022-5347(17)45335-3
PMID:3773120
Abstract

The effects of atropine on bladder contractions evoked by sacral ventral root stimulation were investigated in two species of New World monkey (marmoset and cebus) and in paraplegic man. The findings were then compared to those previously obtained for the cat and two species of Old World monkey (rhesus and baboon). The results show the marmoset and cebus to represent a transitional stage between the complete sensitivity of the bladders of Old World monkeys to atropine and the relative insensitivity of the cat bladder. The bladder response is shown to comprise two components, an atropine sensitive component which is slow in onset and an atropine resistant component which is easily fatigued. The experiments in paraplegic people confirm that the parasympathetic innervation of the bladder of man is, like that of Old World monkeys, exclusively cholinergic. A behavioural interpretation is tentatively offered to explain the two types of innervation.

摘要

在两种新大陆猴(狨猴和卷尾猴)以及截瘫患者中,研究了阿托品对骶神经根刺激诱发的膀胱收缩的影响。然后将这些结果与之前在猫和两种旧大陆猴(恒河猴和狒狒)中获得的结果进行比较。结果表明,狨猴和卷尾猴代表了旧大陆猴膀胱对阿托品完全敏感与猫膀胱相对不敏感之间的过渡阶段。膀胱反应显示由两个成分组成,一个是起效缓慢的阿托品敏感成分,另一个是容易疲劳的阿托品抵抗成分。截瘫患者的实验证实,人类膀胱的副交感神经支配与旧大陆猴一样,完全是胆碱能的。初步提出一种行为学解释来解释这两种神经支配类型。

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