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阿托品作用后猴子的膀胱肌电图及功能

Bladder electromyograms and function in monkeys after atropine.

作者信息

Craggs M D, Stephenson J D

出版信息

Br J Urol. 1985 Jun;57(3):341-5. doi: 10.1111/j.1464-410x.1985.tb06358.x.

DOI:10.1111/j.1464-410x.1985.tb06358.x
PMID:4005504
Abstract

Voiding induced in conscious monkeys by infusion of sterile saline into the bladder via a chronically implanted bladder catheter was stable over many months. Artefact-free recordings of electrical activity were obtained from the bladder neck and dome of these animals during bladder filling and voiding. Characteristic voiding electromyograms were recorded from both sites but were seen first in the record from the neck. Small doses of methyl-atropine abolished both voiding and the electromyograms; evoked responses to sacral ventral root stimulation were similarly prevented. Therefore the bladders of both man and monkey are very sensitive to atropine, unlike the bladders of most other animals.

摘要

通过经长期植入的膀胱导管向清醒猴子的膀胱内注入无菌生理盐水诱导排尿,这种排尿情况在数月内保持稳定。在这些动物的膀胱充盈和排尿过程中,从膀胱颈部和顶部获得了无伪迹的电活动记录。在两个部位都记录到了特征性的排尿肌电图,但首先出现在颈部的记录中。小剂量的甲基阿托品消除了排尿和肌电图;对骶腹根刺激的诱发反应也同样被阻止。因此,与大多数其他动物的膀胱不同,人和猴子的膀胱对阿托品都非常敏感。

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Bladder electromyograms and function in monkeys after atropine.阿托品作用后猴子的膀胱肌电图及功能
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