Rheumatology Division, PMR Department, Marmara University, School of Medicine, Istanbul, Turkey.
PMR Department, Marmara University, School of Medicine, Istanbul, Turkey.
Rheumatol Int. 2018 Jan;38(1):75-81. doi: 10.1007/s00296-017-3882-3. Epub 2017 Nov 14.
Fatigue is a common problem in patients with rheumatic disease. It may cause disability and poor quality of life. The aim of this study is to investigate fatigue in FMF patients as a disabling symptom and its associations with clinical and demographic variables. FMF patients were recruited into the study according to FMF Tel Hashomer criteria. Control group is composed of healthy individuals. Demographic and clinical features of the patients including PRAS scores were noted. Visual analogue score of pain (VAS-pain) and VAS-fatigue were used as clinical parameters. Pittsburgh Sleep Quality Index (PSQI), Multidimensional Assessment of Fatigue (MAF), Nottingham Health Profile (NHP), Fatigue Severity Scale (FSS), Fatigue Impact Scale (FIS) and Hospital Anxiety and Depression Scale (HADS) were filled out by both control and study group. Sixty-one FMF patients and 61 age and gender (44 female, 17 male in each group)-matched controls were enrolled into the study. Mean age of FMF and control group were 35.5 ± 11.8 and 35.8 ± 11.7 years, respectively. The mean disease duration was 82.5 ± 81.7 months. Difference between mean of VAS-pain, VAS-fatigue, PSQI total score, MAF, all subsets of NHP, FSS, FIS, and HADS scores of FMF patients was significantly higher than of control group (p = 0.0001). This study has shown that fatigue in FMF is associated with a number of psychological, sleep, quality of life and disease-related factors. FMF group had increased pain, fatigue, sleep disturbance and decreased quality of life compared to control group. FMF patients with fatigue may benefit from pharmacological and psychological interventions which target these factors.
疲劳是风湿性疾病患者的常见问题。它可能导致残疾和生活质量下降。本研究旨在探讨纤维肌痛综合征（FMF）患者的疲劳作为一种致残症状及其与临床和人口统计学变量的关系。FMF 患者根据 FMF Tel Hashomer 标准被纳入研究。对照组由健康个体组成。记录患者的人口统计学和临床特征，包括 PRAS 评分。疼痛视觉模拟评分（VAS-pain）和 VAS 疲劳被用作临床参数。匹兹堡睡眠质量指数（PSQI）、多维疲劳评估（MAF）、诺丁汉健康概况（NHP）、疲劳严重程度量表（FSS）、疲劳影响量表（FIS）和医院焦虑和抑郁量表（HADS）由对照组和研究组填写。共纳入 61 例 FMF 患者和 61 名年龄和性别（每组 44 名女性，17 名男性）匹配的对照组。FMF 和对照组的平均年龄分别为 35.5±11.8 岁和 35.8±11.7 岁。平均病程为 82.5±81.7 个月。FMF 患者的 VAS-pain、VAS-fatigue、PSQI 总分、MAF、NHP 的所有亚组、FSS、FIS 和 HADS 评分的平均值之间的差异显著高于对照组（p=0.0001）。本研究表明，FMF 中的疲劳与许多心理、睡眠、生活质量和疾病相关因素有关。与对照组相比，FMF 组疼痛、疲劳、睡眠障碍和生活质量下降更为明显。有疲劳症状的 FMF 患者可能受益于针对这些因素的药物和心理干预。
