EClinicalMedicine. 2023 Sep 9;64:102193. doi: 10.1016/j.eclinm.2023.102193. eCollection 2023 Oct.
The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019.
We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends.
In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of -0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = -0.41), inflammatory bowel disease (AAPC = -0.72), multiple sclerosis (AAPC = -0.26), psoriasis (AAPC = -0.77), and atopic dermatitis (AAPC = -0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR.
The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively.
The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38).
免疫介导性炎症性疾病（IMIDs）的病因多种多样，针对特定病因的IMIDs发病率趋势鲜有研究。本研究旨在调查1990年至2019年期间IMIDs的发病模式和趋势。
我们收集了1990年至2019年间IMIDs六大主要病因的详细信息，包括哮喘、炎症性肠病、多发性硬化症、类风湿性关节炎、银屑病和特应性皮炎，这些信息来源于2019年全球疾病负担研究。计算了按性别、年龄、地区和病因划分的IMIDs发病数的年均变化百分比（AAPC）和年龄标准化发病率（ASR），以量化时间趋势。
2019年，类风湿性关节炎、特应性皮炎、哮喘、多发性硬化症、银屑病、炎症性肠病分别占新发性IMIDs病例总数的1.59%、36.17%、54.71%、0.09%、6.84%、0.60%。IMIDs的ASR在区域和全球范围内存在显著差异，在高社会人口指数（SDI）地区、高收入的北美和美国最高。在整个人类寿命周期中，六种IMIDs的发病病例年龄分布差异很大。全球范围内，1990年至2019年期间，IMIDs发病病例数呈上升趋势，AAPC为0.68，而ASR呈下降趋势，AAPC为 -0.34。六种IMIDs的发病病例数均有所增加，类风湿性关节炎的ASR上升（0.21，95%可信区间0.18，0.25），而哮喘（AAPC = -0.41）、炎症性肠病（AAPC = -0.72）、多发性硬化症（AAPC = -0.26）、银屑病（AAPC = -0.77）和特应性皮炎（AAPC = -0.15）的ASR下降。在区域和全球层面，总体及六种个体IMID的ASR均随SDI升高而增加。1990年ASR较高的国家，其ASR下降速度更快。
IMIDs的发病模式在全球范围内差异很大。迫切需要创新的预防和综合管理策略，以分别缓解类风湿性关节炎ASR的上升以及其他五种IMIDs新发病例的激增。
全球疾病负担研究由比尔及梅琳达·盖茨基金会资助。本项目由四川省医学科学院·四川省人民医院科研基金资助（2022QN38）。
Zotero 插件
