1990 年至 2019 年自身免疫性疾病患病率的时间趋势。

Temporal trends in the prevalence of autoimmune diseases from 1990 to 2019.

机构信息

Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, Anhui, China; Department of clinical medicine, The Second School of Clinical Medicine, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.

Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, China; Department of clinical medicine, The First School of Clinical Medicine, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.

出版信息

Autoimmun Rev. 2023 Aug;22(8):103359. doi: 10.1016/j.autrev.2023.103359. Epub 2023 May 16.

DOI:10.1016/j.autrev.2023.103359

PMID:37201621

Abstract

AIM

To describe current situation and analyze temporal trends of prevalence for four autoimmune diseases including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS) and psoriasis, at the global, continental, and national levels.

METHODS

The estimates and 95% uncertainty interval (UI) for age-standardized prevalence rate (ASPR) of RA, IBD, MS and psoriasis were obtained from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. ASPR of RA, IBD, MS and psoriasis in 2019 was illustrated at the global, continental, and national levels. Joinpoint regression analysis was adopted to analyze the 1990-2019 temporal trends by calculating the annual percentage change (APC) and average APC (AAPC), as well as their 95% confidence interval (CI).

RESULTS

In 2019, the global ASPR of RA, IBD, MS and psoriasis was 224.25 (95% UI: 204.94 to 245.99), 59.25 (95% UI: 52.78 to 66.47), 21.25 (95% UI: 18.52 to 23.91) and 503.62 (95% UI: 486.92 to 519.22), respectively, with ASPRs generally higher in Europe and America than in Africa and Asia. From 1990 to 2019, the global ASPR increased significantly for RA (AAPC = 0.27%, 95% CI: 0.24 to 0.30; P < 0.001) and decreased significantly for IBD (AAPC = -0.73%, 95% CI: -0.76 to -0.70; P < 0.001), MS (AAPC = -0.22%, 95% CI: -0.25 to -0.18; P < 0.001) and psoriasis (AAPC = -0.93%, 95% CI: -0.95 to -0.91; P < 0.001), with the most substantial changes occurring at different continents and periods. The trends of ASPR of these four autoimmune diseases varied significantly across 204 countries and territories.

CONCLUSIONS

There is a strong heterogeneity in prevalence (2019), as well as their temporal trends (1990-2019) of autoimmune diseases across the world, highlighting the strong distributive inequities of autoimmune diseases worldwide, which may be instructive for better understanding the epidemiology of these diseases, appropriately allocating the medical resources, as well as making relevant health policies.

摘要

目的

描述类风湿关节炎（RA）、炎症性肠病（IBD）、多发性硬化症（MS）和银屑病这四种自身免疫性疾病在全球、大陆和国家层面的流行现状和时间趋势。

方法

从全球疾病、伤害和危险因素研究（GBD）2019 中获取 RA、IBD、MS 和银屑病的年龄标准化患病率（ASPR）估计值和 95%置信区间（CI）。在全球、大陆和国家层面展示 2019 年 RA、IBD、MS 和银屑病的 ASPR。采用 Joinpoint 回归分析，通过计算年变化百分比（APC）和平均 APC（AAPC）及其 95%CI，分析 1990-2019 年的时间趋势。

结果

2019 年，全球 RA、IBD、MS 和银屑病的 ASPR 分别为 224.25（95%CI：204.94 至 245.99）、59.25（95%CI：52.78 至 66.47）、21.25（95%CI：18.52 至 23.91）和 503.62（95%CI：486.92 至 519.22），欧洲和美洲的 ASPR 普遍高于非洲和亚洲。1990 年至 2019 年，全球 RA 的 ASPR 显著上升（AAPC=0.27%，95%CI：0.24 至 0.30；P<0.001），IBD 的 ASPR 显著下降（AAPC=-0.73%，95%CI：-0.76 至 -0.70；P<0.001），MS 的 ASPR 显著下降（AAPC=-0.22%，95%CI：-0.25 至 -0.18；P<0.001），银屑病的 ASPR 显著下降（AAPC=-0.93%，95%CI：-0.95 至 -0.91；P<0.001），且这些变化在不同大陆和时期最为显著。这四种自身免疫性疾病的 ASPR 趋势在 204 个国家和地区存在显著差异。