Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Department of Nephrology, Binzhou People's Hospital Affiliated to Shandong First Medical University, Binzhou, China.
Front Endocrinol (Lausanne). 2023 Sep 4;14:1257430. doi: 10.3389/fendo.2023.1257430. eCollection 2023.
Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a chronic progressive condition. It is also a common cause of end-stage renal disease (ESRD), which is characterized by proteinuria or a progressive decline in the glomerular filtration rate. Due to their dependence on high-energy and aerobic metabolism, renal tubules are more susceptible to the metabolic disturbances associated with DKD, leading to inflammation and fibrosis. Consequently, tubular injury has become a recent research focus, and significant advancements have been made in studying the role of extracellular vesicles in DKD-associated tubular injury. This review aimed to elucidate the mechanisms and potential applications of different types of extracellular vesicles in tubular injury in DKD to provide new insights for the prevention and treatment of DKD.
糖尿病肾病（DKD）是糖尿病严重的微血管并发症，是一种慢性进行性疾病。它也是终末期肾病（ESRD）的常见原因，其特征是蛋白尿或肾小球滤过率逐渐下降。由于肾小管依赖于高能和需氧代谢，因此更容易受到与 DKD 相关的代谢紊乱的影响，导致炎症和纤维化。因此，管状损伤已成为近期研究的重点，并且在研究细胞外囊泡在 DKD 相关管状损伤中的作用方面取得了重大进展。本综述旨在阐明不同类型的细胞外囊泡在 DKD 管状损伤中的机制和潜在应用，为 DKD 的预防和治疗提供新的思路。
