Coscia Francesco, Di Filippo Ester Sara, Gigliotti Paola Virginia, Fanò-Illic Giorgio
Sports Medicine Service of the San Candido-Innichen and Brunico-Bruneck Hospitals, Bolzano-Bozen, San Candido.
Department of Neuroscience Imaging and Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; IIM-Interuniversity Institute of Myology, University "G. d'Annunzio" of Chieti-Pescara, Chieti.
Eur J Transl Myol. 2023 Sep 20;33(3):11804. doi: 10.4081/ejtm.2023.11804.
The authors of the Comments on: Effect of physical activity on long COVID fatigue by Daungsupawong F. and Wiwanitkit V. (2023) have highlighted certain aspects of future research that need to be considered before any conclusions can be drawn regarding the effect of previous physical activity and/or fitness on the course of long-COVID. We can only agree with this need, although we hope that the effects of SARS-CoV-2 infection will become less and less burdensome to manage. As we hypothesise in the last part of the article by Coscia et al. (2023), we think it is crucial to identify the molecular mechanism underlying the atrophic effect (if any) of the described disease states, which could originate from a local inflammatory storm induced by Spike binding to the ACE-2 receptor in muscle. When studies on muscle from patients will be available in sufficient numbers, we will be able to try to answer the still open questions.
关于Daungsupawong F.和Wiwanitkit V.（2023年）所著《身体活动对长新冠疲劳的影响》的评论文章的作者们强调了未来研究的某些方面，在就先前的身体活动和/或健康状况对长新冠病程的影响得出任何结论之前，都需要考虑这些方面。我们只能认同这种必要性，尽管我们希望新冠病毒感染的影响将变得越来越易于应对。正如我们在Coscia等人（2023年）文章的最后部分所假设的那样，我们认为确定所述疾病状态萎缩效应（如果有的话）背后的分子机制至关重要，这种萎缩效应可能源于刺突蛋白与肌肉中的血管紧张素转换酶2（ACE-2）受体结合引发的局部炎症风暴。当有足够数量的患者肌肉研究可用时，我们将能够尝试回答这些仍未解决的问题。
