School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam.
Intellectual Property Office of Vietnam, Hanoi, Vietnam.
Nat Prod Res. 2024 Nov;38(21):3807-3812. doi: 10.1080/14786419.2023.2258544. Epub 2023 Sep 21.
(L.) Wettst (Plantaginaceae), is traditionally used in many countries as neural tonic and memory enhancer, or to relieve acute pain and inflammation. This study described the isolation and identification of one new, bacomoside D (), and seven known phenyl glycosides (-). The structures of isolates were established by analysis of their spectroscopic data or hydrolysis followed by HPLC analysis together with a comparison to those reported in the literature. These compounds were evaluated for antioxidant and anti-inflammatory activities. Among them, compounds and exhibited strong DPPH radical scavenging activity with IC values of 9.77 ± 0.08 and 3.50 ± 0.04 µM, respectively. Compounds and significantly inhibited TNF- production in LPS-stimulated RAW264.7 cells with IC values of 40.60 ± 3.05 and 38.19 ± 1.75 µM, respectively. Furthermore, the active compounds could be efficient inhibitors of oxidants by interfering with the DPPH activity study.
（唇形科水苏属），在许多国家传统上被用作神经滋补剂和增强记忆力的药物，或用于缓解急性疼痛和炎症。本研究描述了一种新的苯苷（）和七种已知的苯苷（-）的分离和鉴定。通过分析其光谱数据或水解产物再经 HPLC 分析并与文献报道的结果进行比较，确定了这些分离物的结构。评估了这些化合物的抗氧化和抗炎活性。其中，化合物和对 DPPH 自由基具有很强的清除活性，IC 值分别为 9.77±0.08 和 3.50±0.04 μM。化合物和显著抑制 LPS 刺激的 RAW264.7 细胞中 TNF-α的产生，IC 值分别为 40.60±3.05 和 38.19±1.75 μM。此外，这些活性化合物可以通过干扰 DPPH 活性来有效抑制氧化剂。
