Peng Ying, Lou Li-Li, Liu Si-Fan, Zhou Le, Huang Xiao-Xiao, Song Shao-Jiang
School of Pharmacy, Shenyang Pharmaceutical University, PR China.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China.
Bioorg Med Chem Lett. 2016 Nov 15;26(22):5501-5506. doi: 10.1016/j.bmcl.2016.10.012. Epub 2016 Oct 7.
Seven new neolignans (1-2, 7-11) and five known compounds (3-6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7-12 exhibited marked nitric oxide (NO) inhibition and compounds 1-4 had a potent necrosis factor-α (TNF-α) inhibitory effect. The results we obtained showed that hawthorn seeds can be regarded as a potential new and cheap source of antioxidants and inflammation inhibitors.
从山楂籽的70%乙醇提取物中分离出7种新的木脂素（1 - 2, 7 - 11）和5种已知化合物（3 - 6, 12）。通过光谱分析确定了它们的结构。对所有分离物的抗氧化和抗炎活性进行了研究。大多数分离物在DPPH试验中表现出中等程度的自由基清除活性，在ABTS和FRAP试验中表现出显著活性。此外，化合物7 - 12表现出显著的一氧化氮（NO）抑制作用，化合物1 - 4具有强大的肿瘤坏死因子-α（TNF-α）抑制作用。我们获得的结果表明，山楂籽可被视为一种潜在的新型廉价抗氧化剂和炎症抑制剂来源。
