Nakamura T, Zen E, Tanaka Y, Fukabori T
Jpn J Med. 1986 Aug;25(3):257-62. doi: 10.2169/internalmedicine1962.25.257.
Various volumes of saline labelled with indocyanine green (ICG) and urea were injected into the pleural cavity of the dogs. The osmolarity of the saline was exactly adjusted to be equal to that of normally occurring pleural liquid. In all experiments ICG remained constant. This suggested that the injected saline were removed via the lymphatics. The lymphatic removal rate increased linearly with the increase in volume of injected saline. Based on the change in urea concentration in the pleural liquid, the turnover of the pleural liquid was studied. The fraction of exchange of pleural liquid is thought to be constant when the volume of the pleural liquid is small but when the volume is increased, this fraction correspondingly decreases. This method is also available in clinical cases.
将不同体积标记有吲哚菁绿（ICG）和尿素的生理盐水注入犬的胸腔。生理盐水的渗透压被精确调整至与正常胸腔积液的渗透压相等。在所有实验中，ICG保持恒定。这表明注入的生理盐水是通过淋巴管清除的。淋巴管清除率随注入生理盐水体积的增加呈线性增加。基于胸腔积液中尿素浓度的变化，对胸腔积液的周转率进行了研究。当胸腔积液量较小时，胸腔积液的交换分数被认为是恒定的，但当积液量增加时，该分数相应降低。这种方法在临床病例中也适用。
