Aiba M, Inatomi K, Homma H
Jpn J Med. 1984 Feb;23(1):27-33. doi: 10.2169/internalmedicine1962.23.27.
Artificial pleural fluids, containing plasma protein from 0.1 to 9.0 g per 100 ml, indocyanine green (ICG) and para-aminohippurate (PAH), were injected into the pleural cavity of dogs. The concentration of these two indicators were measured at a regular time interval, and the lymphatic and non-lymphatic flows and PAH clearance were calculated by Stewart's and Takashina's equations. When the protein concentration in the pleural fluid was less than 4 g per 100 ml, the pleural fluid volume decreased at a rate of 0.20 ml/kg/hour. The decrease was due to pleural fluid drainage by the lymphatic flow, because the inward and outward non-lymphatic flows due to hydro-oncotic forces balanced each other and the net non-lymphatic flow was essentially zero. When the protein concentration was 6 g per 100 ml or more, the decrease of pleural fluid was remarkably attenuated, because of an increase of the inward non-lymphatic flow due to an increase of protein concentration in the pleural fluid. Even in these situations, the lymphatic flow was kept at the rate of 0.20 ml/kg/hour, similarly with the former conditions. From these results, it may be concluded that the lymphatic system is a principal factor, and that factors governed by hydro-oncotic elements have additive effect to that of the lymphatic system in the regulation of pleural fluid dynamics.
将含有每100毫升0.1至9.0克血浆蛋白、吲哚菁绿（ICG）和对氨基马尿酸（PAH）的人工胸水注入犬的胸腔。定期测量这两种指标的浓度，并根据斯图尔特方程和高志方程计算淋巴液和非淋巴液流量以及PAH清除率。当胸水中的蛋白质浓度低于每100毫升4克时，胸水体积以每千克每小时0.20毫升的速度下降。这种下降是由于淋巴液引流导致的胸水排出，因为由于胶体渗透压产生的向内和向外的非淋巴液流量相互平衡，净非淋巴液流量基本为零。当蛋白质浓度为每100毫升6克或更高时，由于胸水中蛋白质浓度增加导致向内的非淋巴液流量增加，胸水的减少明显减弱。即使在这些情况下，淋巴液流量仍保持在每千克每小时0.20毫升的速度，与之前的情况类似。从这些结果可以得出结论，淋巴系统是一个主要因素，并且在胸水动力学调节中，由胶体渗透压因素控制的因素对淋巴系统的作用具有累加效应。
