Mitsuyama Y, Fujimoto S, Kohno T
Jpn J Psychiatry Neurol. 1986 Mar;40(1):105-12. doi: 10.1111/j.1440-1819.1986.tb01617.x.
This is a clinico-pathological study of one case of acute hemorrhagic leukoencephalitis occurring in a patient with lung cancer. The main changes observed by light microscopy were in the white matter. All of these changes were the result of hemorrhage and demyelination around the venous vessels. Glial mesenchymal reactions were minimal. In view of these findings, this case supports the hypothesis that immune mechanisms play a role in the pathogenesis of neuropsychiatric symptoms during malignant illnesses. Here we will discuss the problem of differential diagnoses of acute hemorrhagic leukoencephalitis and its close morphologic similarities to perivenous encephalitis. Acute hemorrhagic leukoencephalitis and perivenous encephalitis may be a single entity of a demyelinating disease.
这是对一名肺癌患者发生的急性出血性白质脑炎病例的临床病理研究。光镜下观察到的主要变化位于白质。所有这些变化都是静脉血管周围出血和脱髓鞘的结果。胶质间充质反应轻微。鉴于这些发现，该病例支持免疫机制在恶性疾病期间神经精神症状发病机制中起作用的假说。在此我们将讨论急性出血性白质脑炎的鉴别诊断问题及其与静脉周围脑炎在形态学上的密切相似性。急性出血性白质脑炎和静脉周围脑炎可能是脱髓鞘疾病的单一实体。
