Davidson T, Wallace J, Carnochan P
Lab Anim. 1986 Oct;20(4):343-6. doi: 10.1258/002367786780808703.
Regional delivery of chemotherapy to a tumour or tumour-bearing region has pharmacokinetic advantages over the systemic route. The applications of an animal model for regional drug delivery are outlined. The technique for intra-arterial infusion in the rabbit hindlimb is described. The use of the implantable VX2 rabbit carcinoma as a model for solid human tumours may be studied by this method. Pharmacokinetic data obtained with the model allow comparison between systemic and regional routes of delivery. The distribution of the cancerostatic plant toxin ricin following regional delivery has been investigated using this experimental model.
与全身给药途径相比，向肿瘤或肿瘤所在区域进行区域化疗具有药代动力学优势。概述了动物模型在区域药物递送中的应用。描述了兔后肢动脉内灌注技术。可通过该方法研究将可植入VX2兔癌作为实体人类肿瘤模型的应用。用该模型获得的药代动力学数据可比较全身和区域给药途径。已使用该实验模型研究了区域给药后抗癌植物毒素蓖麻毒素的分布。
