Department of Physiology and Biomedical Engineering, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Robert and Arlene Kogod Center on Aging, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Cold Spring Harb Perspect Med. 2024 Feb 1;14(2):a041205. doi: 10.1101/cshperspect.a041205.
Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead. They noted sustained cell-cycle arrest after repeated subculturing of human primary cells. Over half a century later, cellular senescence has become recognized as one of the fundamental pillars of aging. Developing senotherapeutics, interventions that selectively eliminate or target senescent cells, has emerged as a key focus in health research. In this article, we note major milestones in cellular senescence research, discuss current challenges, and point to future directions for this rapidly growing field.
细胞衰老最初是在 20 世纪 60 年代由 Hayflick 和 Moorehead 描述的。他们注意到在反复传代培养人类原代细胞后，细胞周期持续停滞。半个多世纪后，细胞衰老已被公认为衰老的基本支柱之一。开发选择性消除或靶向衰老细胞的衰老疗法已成为健康研究的一个关键重点。在本文中，我们注意到细胞衰老研究的主要里程碑，讨论当前的挑战，并为这个快速发展的领域指出未来的方向。
