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A revolution in obesity treatment.

作者信息

Lingvay Ildiko, Agarwal Shubham

机构信息

Division of Endocrinology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Peter O'Donnell Jr School of Public Health, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

出版信息

Nat Med. 2023 Oct;29(10):2406-2408. doi: 10.1038/s41591-023-02538-7.

DOI:10.1038/s41591-023-02538-7
PMID:37735562
Abstract
摘要

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1
A revolution in obesity treatment.肥胖治疗的一场革命。
Nat Med. 2023 Oct;29(10):2406-2408. doi: 10.1038/s41591-023-02538-7.
2
Dr. Atkins' diet revolution: a review.阿特金斯博士的饮食革命:一篇综述。
Va Med Mon (1918). 1974 May;101(5):383-5.
3
A critique of low-carbohydrate ketogenic weight reduction regimens. A review of Dr. Atkins' diet revolution.对低碳水化合物生酮减肥方案的批判。阿特金斯博士《饮食革命》述评。
JAMA. 1973 Jun 4;224(10):1415-9. doi: 10.1001/jama.1973.03220240055018.
4
[Comments on obesity; Brillat-Savarin and the treatment of obesity].[关于肥胖症的评论;布里亚-萨瓦兰与肥胖症治疗]
Rev Iber Endocrinol. 1956 May-Jun;3(15):331-6.
5
Advancing the revolution in the behavioral treatment of obesity.推动肥胖行为治疗的革命。
Obesity (Silver Spring). 2016 Oct;24(10):2029-30. doi: 10.1002/oby.21641.
6
[Obesity: Progress in diagnosis and treatment; Topics, II. Progress in treatment; 1. Behavioral therapy for obesity].[肥胖症:诊断与治疗进展;主题,二、治疗进展;1. 肥胖症的行为疗法]
Nihon Naika Gakkai Zasshi. 2011 Apr 10;100(4):917-27. doi: 10.2169/naika.100.917.
7
[Treatment of android obesity and its complications].[男性型肥胖症及其并发症的治疗]
Alger Medicale. 1956 Feb;60(2):91-9.
8
A second vaccine revolution for the new epidemics of the 21st century.21世纪新流行病的第二次疫苗革命。
Drug Discov Today. 2006 Nov;11(21-22):1028-33. doi: 10.1016/j.drudis.2006.09.006. Epub 2006 Sep 26.
9
Operative treatment of abdominal obesity, especially pendulous abdomen.腹部肥胖症的手术治疗,尤其是悬垂腹。
Br J Plast Surg. 1949 Jan;1(4):274-83.
10
Obesity treatment: the high cost of false hope.肥胖症治疗:虚假希望的高昂代价。
J Am Diet Assoc. 1991 Oct;91(10):1248-51.

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From BMI to Disease Diagnosis: What Clinical and Pre-clinical Obesity Mean for Surgeons.从体重指数到疾病诊断:临床和临床前肥胖对外科医生的意义。
Obes Surg. 2025 Aug 13. doi: 10.1007/s11695-025-08159-y.
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Emerging evidence and potential avenues to achieve durable outcomes in patients with obesity: the confluence of nutrition, and Microbiome on body composition.肥胖患者实现持久疗效的新证据和潜在途径:营养与微生物群对身体成分的共同影响
Rev Endocr Metab Disord. 2025 Jul 2. doi: 10.1007/s11154-025-09977-2.
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Factors influencing the selection of an SGLT2i vs. a GLP-1RA as cardioprotective agent in patients with type 2 diabetes.

本文引用的文献

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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.Retatrutide,一种胰高血糖素样肽-1(GLP-1)和胰高血糖素受体双重激动剂,用于治疗 2 型糖尿病患者:一项在美国进行的随机、双盲、安慰剂和阳性对照、平行组、2 期临床试验。
Lancet. 2023 Aug 12;402(10401):529-544. doi: 10.1016/S0140-6736(23)01053-X. Epub 2023 Jun 26.
2
Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial.在 2 型糖尿病成人中,每日口服一次司美格鲁肽 25mg 和 50mg 与 14mg 相比的疗效和安全性(PIONEER PLUS):一项多中心、随机、3b 期临床试验。
Lancet. 2023 Aug 26;402(10403):693-704. doi: 10.1016/S0140-6736(23)01127-3. Epub 2023 Jun 26.
3
影响2型糖尿病患者选择钠-葡萄糖协同转运蛋白2抑制剂(SGLT2i)与胰高血糖素样肽-1受体激动剂(GLP-1RA)作为心脏保护药物的因素。
Front Cardiovasc Med. 2025 May 23;12:1606198. doi: 10.3389/fcvm.2025.1606198. eCollection 2025.
4
Diabetes and Glucose Management in People on Hemodialysis.血液透析患者的糖尿病与血糖管理
Diabetes Spectr. 2025 Feb 14;38(1):7-18. doi: 10.2337/dsi24-0015. eCollection 2025 Winter.
5
Glucagon-like peptide 1 (GLP1) receptor agonists and risk for ischemic optic neuropathy: A meta-analysis of randomised controlled trials.胰高血糖素样肽1(GLP1)受体激动剂与缺血性视神经病变风险:一项随机对照试验的荟萃分析
Diabetes Obes Metab. 2025 Feb;27(2):1005-1009. doi: 10.1111/dom.16076. Epub 2024 Nov 20.
6
Hepatic protein phosphatase 1 regulatory subunit 3G alleviates obesity and liver steatosis by regulating the gut microbiota and bile acid metabolism.肝脏蛋白磷酸酶1调节亚基3G通过调节肠道微生物群和胆汁酸代谢来减轻肥胖和肝脂肪变性。
J Pharm Anal. 2024 Aug;14(8):100976. doi: 10.1016/j.jpha.2024.100976. Epub 2024 Apr 11.
7
Diabetes Technology in People with Type 2 Diabetes: Novel Indications.2 型糖尿病患者的糖尿病技术:新适应证。
Curr Diab Rep. 2024 May;24(5):85-95. doi: 10.1007/s11892-024-01536-4. Epub 2024 Feb 29.
8
Risk Stratification and Treatment of Obesity for Primary and Secondary Prevention of Cardiovascular Disease.肥胖的风险分层与治疗用于心血管疾病的一级和二级预防
Curr Atheroscler Rep. 2024 Jan;26(1):11-23. doi: 10.1007/s11883-023-01182-3. Epub 2023 Dec 30.
9
Keeping the weight off.保持体重不增加。
Nat Med. 2023 Oct;29(10):2377-2378. doi: 10.1038/s41591-023-02614-y.
Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial.每日口服司美格鲁肽 50mg 治疗超重或肥胖成人(OASIS 1 研究):一项随机、双盲、安慰剂对照、3 期临床试验。
Lancet. 2023 Aug 26;402(10403):705-719. doi: 10.1016/S0140-6736(23)01185-6. Epub 2023 Jun 26.
4
Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.司美格鲁肽每周一次治疗 2 型糖尿病患者的肥胖症(SURMOUNT-2):一项双盲、随机、多中心、安慰剂对照、3 期临床试验。
Lancet. 2023 Aug 19;402(10402):613-626. doi: 10.1016/S0140-6736(23)01200-X. Epub 2023 Jun 26.
5
Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial.三重激素受体激动剂 Retatrutide 治疗肥胖症的 2 期临床试验
N Engl J Med. 2023 Aug 10;389(6):514-526. doi: 10.1056/NEJMoa2301972. Epub 2023 Jun 26.
6
Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial.在 2 型糖尿病患者中联合应用每周一次 2·4 mg 卡格列净和每周一次 2·4 mg 司美格鲁肽的疗效和安全性:一项多中心、随机、双盲、阳性对照、2 期临床试验。
Lancet. 2023 Aug 26;402(10403):720-730. doi: 10.1016/S0140-6736(23)01163-7. Epub 2023 Jun 23.
7
Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity.每日口服 GLP-1 受体激动剂奥福格鲁波治疗成年人肥胖症。
N Engl J Med. 2023 Sep 7;389(10):877-888. doi: 10.1056/NEJMoa2302392. Epub 2023 Jun 23.
8
Gut hormone co-agonists for the treatment of obesity: from bench to bedside.用于肥胖治疗的胃肠激素共激动剂:从基础到临床。
Nat Metab. 2023 Jun;5(6):933-944. doi: 10.1038/s42255-023-00812-z. Epub 2023 Jun 12.
9
Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes: A Randomized Clinical Trial.口服小分子胰高血糖素样肽-1 受体激动剂达努鲁肽在 2 型糖尿病患者血糖控制中的疗效和安全性:一项随机临床试验。
JAMA Netw Open. 2023 May 1;6(5):e2314493. doi: 10.1001/jamanetworkopen.2023.14493.
10
Tirzepatide Once Weekly for the Treatment of Obesity.司美格鲁肽每周一次治疗肥胖症。
N Engl J Med. 2022 Jul 21;387(3):205-216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4.