Wilpizeski C R, Lowry L D, Goldman W S
Laryngoscope. 1986 Nov;96(11):1221-5. doi: 10.1002/lary.1986.96.11.1221.
Using squirrel monkeys as experimental subjects, we reexamined the disputed role of the area postrema (AP) in motion-induced vomiting. After anesthetization, the obex and rhomboid fossa were exposed surgically, and the AP was ablated by thermal coagulation using either a battery cautery or a CO2 microsurgical laser. Sham operations were performed on another sample of monkeys. Two or more weeks after surgery, all animals were given 10 daily 2-hour horizontal rotations at 30 rpm. Every monkey in both the lesions and sham samples vomited on two or more test days. While the vomiting characteristics were modified following ablation of AP, its function is not indispensible for the development of motion sickness in horizontally-rotated squirrel monkeys.
以松鼠猴作为实验对象，我们重新审视了最后区（AP）在运动诱发呕吐中存在争议的作用。麻醉后，通过手术暴露闩和菱形窝，使用电池烧灼器或二氧化碳显微外科激光通过热凝法切除AP。对另一组猴子进行假手术。术后两周或更长时间，所有动物每天以30转/分钟的速度进行10次每次2小时的水平旋转。损伤组和假手术组的每只猴子在两个或更多测试日都出现了呕吐。虽然切除AP后呕吐特征有所改变，但其功能对于水平旋转的松鼠猴晕动病的发生并非不可或缺。
